Active tuberculosis process in female patient with asymptomatic clinical course of malignant neoplasm in the pulmonary tissue
- Authors: Chumovatov N.V.1, Ainsanova A.A.1, Chernykh N.A.1, Khozikov A.S.1, Komissarova O.G.1,2
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Affiliations:
- Central Research Institute of Tuberculosis
- N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia
- Issue: Vol 11, No 1 (2025)
- Pages: 134-139
- Section: CLINICAL CASE
- URL: https://bakhtiniada.ru/2412-4036/article/view/292575
- DOI: https://doi.org/10.18565/therapy.2025.1.134-139
- ID: 292575
Cite item
Abstract
In modern phthisiology, the problem of combination of pulmonary tuberculosis and malignant neoplasms (MN) is actual. According to research data, in case of MN, the risk of tuberculosis arising in patients increases by 6 times. At the same time, the presence of an active tuberculosis process (ATP) in lung tissue increases the probability of lung cancer by 3 times or more. In addition, the interaction of these two diseases can reduce the anti-tumor effect of immune system. This situation can lead to a long-term asymptomatic clinical course of oncological process coming secondary to active pulmonary tuberculosis. The aim of the article is to demonstrate the combination of ATP and asymptomatic clinical course of malignant neoplasms. The presented clinical example demonstrates the difficulties of diagnosis and choice of treatment tactics in such category of patients. Actual direction in modern phthisiology is high oncological alertness to comorbid patients with pulmonary tuberculosis.
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##article.viewOnOriginalSite##About the authors
Nikita V. Chumovatov
Central Research Institute of Tuberculosis
Author for correspondence.
Email: Necro5412@mail.ru
ORCID iD: 0000-0001-8745-7940
MD, PhD (Medicine), researcher at the Department of phthisiology
Russian Federation, 107564, Moscow, 2 Yauzskaya AlleyAsel A. Ainsanova
Central Research Institute of Tuberculosis
Email: asel.ainsanova@gmail.com
ORCID iD: 0009-0001-5593-6872
MD, laboratory assistant-researcher at the Department of phthisiology
Russian Federation, 107564, Moscow, 2 Yauzskaya AlleyNatalya A. Chernykh
Central Research Institute of Tuberculosis
Email: natadok@inbox.ru
ORCID iD: 0000-0001-6787-2362
MD, PhD (Medicine), senior researcher at the Department of phthisiology
Russian Federation, 107564, Moscow, 2 Yauzskaya AlleyAndrey S. Khozikov
Central Research Institute of Tuberculosis
Email: hozikov96@mail.ru
ORCID iD: 0000-0003-0308-9592
MD, pathologist
Russian Federation, 107564, Moscow, 2 Yauzskaya AlleyOksana G. Komissarova
Central Research Institute of Tuberculosis; N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia
Email: oksana.komissarova.72@mail.ru
ORCID iD: 0000-0003-4427-3804
MD, Dr. Sci. (Medicine), associate professor, deputy director for scientific and medical work of the Department of phthisiology
Russian Federation, 107564, Moscow, 2 Yauzskaya Alley; 1 bldg. 6 Ostrovityanova ulitsa, Moscow 117513References
- Васильева И.А., Тестов В.В., Стерликов С.А. Эпидемическая ситуация по туберкулезу в годы пандемии COVID-19 – 2020–2021 гг. Туберкулез и болезни легких. 2022; 100(3): 6–12. [Vasilyeva I.A., Testov V.V., Sterlikov S.A. Tuberculosis situation in the years of the COVID-19 pandemic – 2020–2021. Tuberkulez i bolezni legkikh = Tuberculosis and Lung Diseases. 2022; 100(3): 6–12 (In Russ.)]. https://doi.org/10.21292/2075-1230-2022-100-3-6-12. EDN: DPMDCF.
- Cheng M.P., Chakra C.N.A., Yansouni C.P. et al. Risk of active tuberculosis in patients with cancer: A systematic review and meta-analysis. Clin Infect Dis. 2017; 64(5): 635–44. https://doi.org/10.1093/cid/ciw838. PMID: 27986665.
- Engels E.A., Shen M., Chapman R.S. et al. Tuberculosis and subsequent risk of lung cancer in Xuanwei, China. Int J Cancer. 2009; 124(5): 1183–87. https://doi.org/10.1002/ijc.24042. PMID: 19058197. PMCID: PMC2610239.
- An S.J., Kim Y.-J., Han S.-S., Heo J. Effects of age on the association between pulmonary tuberculosis and lung cancer in a South Korean cohort. J Thorac Dis. 2020; 12(3): 375–82. https://doi.org/10.21037/jtd.2020.01.38. PMID: 32274103. PMCID: PMC7139000.
- Gong W., Liang Y., Wu X. Animal models of tuberculosis vaccine research: An important component in the fight against tuberculosis. Biomed Res Int. 2020; 2020: 4263079. https://doi.org/10.1155/2020/4263079. PMID: 32025519. PMCID: PMC6984742.
- Mi J., Liang Y., Liang J. et al. The research progress in immunotherapy of tuberculosis. Front Cell Infect Microbiol. 2021; 11: 763591. https://doi.org/10.3389/fcimb.2021.763591. PMID: 34869066. PMCID: PMC8634162.
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