Modern tendencies of influence on skin microbiome by means of dermatocosmetics: practical aspects of probiotic bacteria application in the composition of biotic complexes

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In the last few decades, the number of studies on the microbiota and microbiome of living organisms inhabiting the skin has grown rapidly, and the contribution of the microbial community to the realization of skin functions and the pathogenesis of dermatoses is of great scientific and public interest. Understanding the contribution of skin dysbiosis to skin aging, sensitization, and the pathogenesis of chronic dermatoses has prompted the development of strategies aimed at correcting the skin microbiota.

One of the directions of bacteriotherapy of skin diseases is the use of biotic complexes, which include metabiotics of human commensal bacteria and prebiotics. The use of biotic complexes allows to effectively modulate the skin microbiome and its barrier functions.

A practical embodiment of the use of metabiotics of probiotic bacteria as part of biotic complexes was the development of active skin care systems containing lysates of probiotic microorganisms Lactococcus, Lactobacillus and Bifidobacterium and prebiotics trehalose and inulin. These products can be enhanced with active ingredients with proven efficacy, such as panthenol, jojoba oil, shea butter and others that provide skin cleansing, moisturizing and nourishing. The conducted studies have demonstrated the effectiveness and safety of products with enhanced formula as part of complex treatment of patients with atopic dermatitis. Their clinical effects are based on the restoration of the skin barrier (according to the dynamics of pH-metry, transepidermal water loss and skin elasticity), as well as normalization of the microbial composition of the skin (reduction in the frequency of identification of phylum, which belong to opportunistic microorganisms, and reduction in the frequency of identification of the Staphylococcaceae family, pathogenic representatives of which lead to increased inflammation and allergic reactions on the skin).

作者简介

Vladimir Adaskevich

Vitebsk State Order of Peoples' Friendship Medical University

Email: Vitebsk-derma@mail.ru
ORCID iD: 0000-0002-5700-9829
SPIN 代码: 3721-9080

MD, Dr. Sci. (Medicine), Professor

白俄罗斯, Vitebsk

Aleksei Gorodovich

Polotsk Central City Hospital

Email: polotsk.mod@gmail.com
白俄罗斯, Polotsk

Denis Zaslavsky

Saint-Petersburg State Pediatric Medical University

Email: venerology@gmail.com
ORCID iD: 0000-0001-5936-6232
SPIN 代码: 5832-9510

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Saint Petersburg

Vitaly Okhlopkov

Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology

Email: vokhlopkov@fnkcrr.ru
ORCID iD: 0000-0002-3515-6027
SPIN 代码: 1202-6653

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Solnechnogorsk, Lytkino village

Irina Smirnova

Saint-Petersburg State University; City Skin and Venereological Dispensary

Email: driosmirnova@yandex.ru
ORCID iD: 0000-0001-8584-615X
SPIN 代码: 5518-6453

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Saint Petersburg; 3 Volkovka river embankment, Saint Petersburg, 192102

Alexey Taganov

Pierre Wolkenstein Clinic of Skin Diseases

Email: matis87177@yandex.ru
ORCID iD: 0000-0001-5056-374X
SPIN 代码: 1191-8991

MD, Dr. Sci. (Medicine)

俄罗斯联邦, Saint Petersburg

Olga Tamrazova

Peoples' Friendship University of Russia

Email: anait_tamrazova@mail.ru
ORCID iD: 0000-0003-3261-6718
SPIN 代码: 5476-8497

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Moscow

Irena Shlivko

Privolzhsky Research Medical University

Email: irshlivko@gmail.com
ORCID iD: 0000-0001-7253-7091
SPIN 代码: 8301-4815

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Nizhny Novgorod

Kristina Khazhomiya

City Skin and Venereological Dispensary

编辑信件的主要联系方式.
Email: christinakhazhomiya@gmail.com
ORCID iD: 0000-0002-2997-6109
SPIN 代码: 2796-4870
俄罗斯联邦, 3 Volkovka river embankment, Saint Petersburg, 192102

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