Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors
- 作者: Butov G.M.1, Burmistrov V.V.1, D’yachenko V.S.1
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隶属关系:
- Volzhskii Polytechnic Institute (Branch)
- 期: 卷 53, 编号 7 (2017)
- 页面: 977-980
- 栏目: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/216501
- DOI: https://doi.org/10.1134/S107042801707003X
- ID: 216501
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详细
Self-condensation of substituted adamantan-1-yl isocyanates in THF in the presence of DBU afforded 91–96% of symmetrical ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors. The described reaction avoids the use of the corresponding amine as counterpart. The obtained ureas are characterized by reduced melting points and improved solubility in water.
作者简介
G. Butov
Volzhskii Polytechnic Institute (Branch)
编辑信件的主要联系方式.
Email: butov@volpi.ru
俄罗斯联邦, ul. Engel’sa 42a, Volzhskii, Volgograd oblast, 404121
V. Burmistrov
Volzhskii Polytechnic Institute (Branch)
Email: butov@volpi.ru
俄罗斯联邦, ul. Engel’sa 42a, Volzhskii, Volgograd oblast, 404121
V. D’yachenko
Volzhskii Polytechnic Institute (Branch)
Email: butov@volpi.ru
俄罗斯联邦, ul. Engel’sa 42a, Volzhskii, Volgograd oblast, 404121
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