Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors
- Авторы: Butov G.M.1, Burmistrov V.V.1, D’yachenko V.S.1
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Учреждения:
- Volzhskii Polytechnic Institute (Branch)
- Выпуск: Том 53, № 7 (2017)
- Страницы: 977-980
- Раздел: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/216501
- DOI: https://doi.org/10.1134/S107042801707003X
- ID: 216501
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Аннотация
Self-condensation of substituted adamantan-1-yl isocyanates in THF in the presence of DBU afforded 91–96% of symmetrical ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors. The described reaction avoids the use of the corresponding amine as counterpart. The obtained ureas are characterized by reduced melting points and improved solubility in water.
Об авторах
G. Butov
Volzhskii Polytechnic Institute (Branch)
Автор, ответственный за переписку.
Email: butov@volpi.ru
Россия, ul. Engel’sa 42a, Volzhskii, Volgograd oblast, 404121
V. Burmistrov
Volzhskii Polytechnic Institute (Branch)
Email: butov@volpi.ru
Россия, ul. Engel’sa 42a, Volzhskii, Volgograd oblast, 404121
V. D’yachenko
Volzhskii Polytechnic Institute (Branch)
Email: butov@volpi.ru
Россия, ul. Engel’sa 42a, Volzhskii, Volgograd oblast, 404121
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