Email this article Synthesis and properties of symmetrical N,N'-Bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors
- Authors: Butov G.M.1, Burmistrov V.V.1, D’yachenko V.S.1
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Affiliations:
- Volzhskii Polytechnic Institute (Branch)
- Issue: Vol 53, No 7 (2017)
- Pages: 977-980
- Section: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/216501
- DOI: https://doi.org/10.1134/S107042801707003X
- ID: 216501
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Abstract
Self-condensation of substituted adamantan-1-yl isocyanates in THF in the presence of DBU afforded 91–96% of symmetrical ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors. The described reaction avoids the use of the corresponding amine as counterpart. The obtained ureas are characterized by reduced melting points and improved solubility in water.
About the authors
G. M. Butov
Volzhskii Polytechnic Institute (Branch)
Author for correspondence.
Email: butov@volpi.ru
Russian Federation, ul. Engel’sa 42a, Volzhskii, Volgograd oblast, 404121
V. V. Burmistrov
Volzhskii Polytechnic Institute (Branch)
Email: butov@volpi.ru
Russian Federation, ul. Engel’sa 42a, Volzhskii, Volgograd oblast, 404121
V. S. D’yachenko
Volzhskii Polytechnic Institute (Branch)
Email: butov@volpi.ru
Russian Federation, ul. Engel’sa 42a, Volzhskii, Volgograd oblast, 404121
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