Synthesis and antitubercular activity of first glucuronosyl phosphates and amidophosphates containing polymethylene chains

E. S. Izmest’ev; O. V. Andreeva; R. R. Sharipova; M. A. Kravchenko; B. F. Garifullin; I. Yu. Strobykina; V. E. Kataev; V. F. Mironov

doi:10.1134/S1070428017010092

Synthesis and antitubercular activity of first glucuronosyl phosphates and amidophosphates containing polymethylene chains

Autores: Izmest’ev E.S.¹, Andreeva O.V.¹, Sharipova R.R.¹, Kravchenko M.A.², Garifullin B.F.¹, Strobykina I.Y.¹, Kataev V.E.¹, Mironov V.F.¹
Afiliações:
1. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
2. Ural Research Institute of Phthisiopulmonology
Edição: Volume 53, Nº 1 (2017)
Páginas: 51-56
Seção: Article
URL: https://bakhtiniada.ru/1070-4280/article/view/215609
DOI: https://doi.org/10.1134/S1070428017010092
ID: 215609

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Resumo

Novel phosphorylated glycolipids based on glucuronic acid have been synthesized and shown to inhibit M. Tuberculosis H37Rv in vitro at a minimum inhibitory concentration of 12.5 μg/mL.