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Yamaguchi Esterification in the Synthetic Approaches to Precursors of Epothilone D Analogs


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Abstract

Coupling of previously synthesized chiral building blocks via Yamaguchi esterification has been studied with the goal of obtaining epothilone D isosteres. Some peculiar features of the Yamaguchi esterification stage have been revealed, which are related to the reactivity and molecular structure of the initial acid and alcohol components.

About the authors

R. F. Valeev

Ufa Institute of Organic Chemistry, Ufa Federal Research Center

Author for correspondence.
Email: rusl0@yandex.ru
Russian Federation, Ufa, Bashkortostan

G. R. Sunagatullina

Ufa Institute of Organic Chemistry, Ufa Federal Research Center

Email: rusl0@yandex.ru
Russian Federation, Ufa, Bashkortostan

M. S. Miftakhov

Ufa Institute of Organic Chemistry, Ufa Federal Research Center

Email: rusl0@yandex.ru
Russian Federation, Ufa, Bashkortostan

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