Yamaguchi Esterification in the Synthetic Approaches to Precursors of Epothilone D Analogs


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Coupling of previously synthesized chiral building blocks via Yamaguchi esterification has been studied with the goal of obtaining epothilone D isosteres. Some peculiar features of the Yamaguchi esterification stage have been revealed, which are related to the reactivity and molecular structure of the initial acid and alcohol components.

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R. Valeev

Ufa Institute of Organic Chemistry, Ufa Federal Research Center

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Email: rusl0@yandex.ru
俄罗斯联邦, Ufa, Bashkortostan

G. Sunagatullina

Ufa Institute of Organic Chemistry, Ufa Federal Research Center

Email: rusl0@yandex.ru
俄罗斯联邦, Ufa, Bashkortostan

M. Miftakhov

Ufa Institute of Organic Chemistry, Ufa Federal Research Center

Email: rusl0@yandex.ru
俄罗斯联邦, Ufa, Bashkortostan

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