Yamaguchi Esterification in the Synthetic Approaches to Precursors of Epothilone D Analogs

R. F. Valeev; G. R. Sunagatullina; M. S. Miftakhov

doi:10.1134/S1070428019090264

Yamaguchi Esterification in the Synthetic Approaches to Precursors of Epothilone D Analogs

作者: Valeev R.F.¹, Sunagatullina G.R.¹, Miftakhov M.S.¹
隶属关系:
1. Ufa Institute of Organic Chemistry, Ufa Federal Research Center
期: 卷 55, 编号 9 (2019)
页面: 1439-1441
栏目: Short Communications
URL: https://bakhtiniada.ru/1070-4280/article/view/221235
DOI: https://doi.org/10.1134/S1070428019090264
ID: 221235

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详细

Coupling of previously synthesized chiral building blocks via Yamaguchi esterification has been studied with the goal of obtaining epothilone D isosteres. Some peculiar features of the Yamaguchi esterification stage have been revealed, which are related to the reactivity and molecular structure of the initial acid and alcohol components.