First catalyst- and solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones


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Abstract

A completely green and environmentally benign Biginelli synthesis of 3,4-dihydropyrimidine-2(1H)-ones and -thiones by one-pot three-component reaction of aromatic aldehydes with ethyl acetoacetate and urea or thiourea without any catalyst under solvent-free conditions is described.

About the authors

M. Hajjami

Department of Chemistry, Faculty of Science

Author for correspondence.
Email: mhajjami@yahoo.com
Iran, Islamic Republic of, Ilam

E. Ghiasbeygi

Department of Chemistry, Faculty of Science

Email: mhajjami@yahoo.com
Iran, Islamic Republic of, Ilam

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