First catalyst- and solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones

Resumo

A completely green and environmentally benign Biginelli synthesis of 3,4-dihydropyrimidine-2(1H)-ones and -thiones by one-pot three-component reaction of aromatic aldehydes with ethyl acetoacetate and urea or thiourea without any catalyst under solvent-free conditions is described.