Prognostic Value for Parameters of the Hemostasis System during Parvovirus Infection of Carnivores

Abstract

Abstract—Prognostic significance of the hemostasis system’s parameters in dogs with parvovirus infection has been evaluated. Blood test results of dead (n = 4) and surviving dogs (n = 11) on the third and fifth day of illness at 2–6-months of age were compared with each other and with results from the blood test of healthy dogs in the control group (n = 10). By the third day of the disease, as markers of an unfavorable prognosis, one can distinguish a decrease in platelet count to 285.97 ± 14.84 × 10⁹/L, an increase in the average platelet volume to 8.5 ± 1.7 fl, and platelet survival time (PST) to 0.53 ± 0.02%, summing up of the platelet aggregation index with ADP induction aggregators to 131.67 ± 9.28% and ristomycin to 127.77 ± 14.71%, a decrease in disaggregation with ADP aggregation inducers to 1.03 ± 1.03% and ristomycin to 0.08 ± 0.08%, an increase in the amount of fibrinogen to 5.2 ± 0.49 g/L and soluble fibrin-monomer complexes to 12.97 ± 1.15 mg/100 mL with a decrease in antithrombin activity to 105.3 ± 3.16%. By the fifth day of illness, the risk of death is associated with such parameters as a progressive decrease in platelet count to 227 ± 15.64 × 10⁹/L with a decrease in the average platelet volume to 5.5 ± 1.2 fl as well as PST to 0.21 ± 0.03% with a summing platelet aggregation index with ADP aggregation inducers to 31.67 ± 12.03%, with collagen to 15.53 ± 4.26%, and ristomycin to 14.8 ± 5.6%; a decrease in disaggregation with ADP by 81%, with collagen by 77%, and with ristomycin by 98.7%; an increase in prothrombin time from 14.17 ± 0.24 to 18.5 ± 2.9 s, thrombin time from 9.07 ± 0.58 to 15.3 ± 2.08 s, and activated partial thromboplastin time from 18.03 ± 1.54 to 26.37 ± 1.57 s as well as soluble fibrin-monomer complexes to 17.3 ± 1.17 mg/100 mL; a decrease in the amount of fibrinogen to 2.73 ± 0.89 g/L and antithrombin activity to 88.63 ± 14.93%.