Cytokine profile of albino rats’ changes under the impact of Salmonella against the background of subacute T-2 toxicosis

Abstract

The results of the study demonstrated the immunosuppression in albino rats under a complex impact of T-2 toxin and Salmonella, manifested by the significant increase of anti-inflammatory cytokine IL-1β content in the blood and a slight increase of IL-4, stimulating the humoral immunity, the decrease of concentration of other anti-inflammatory mediators (TNF-α, IL-8), immunoregulatory interleukins IL-2, interferon-γ and anti-inflammatory cytokine IL-10, and interferon–γ/IL-4 ratio, indicating an evident T-deficit and a more significant suppression of Th-1 lymphocyte function.