The distribution of complexes  69m ZnL 1 Cl 2 , [ 69m Zn(L 2 ) 2 ]Cl 2 , and [ 69m Zn(L 2 ) 2 ]Sal 2  (L 1  is  N -(5,6-dihydro-4 H -1,3-thiazin-2-yl)benzamide, L 2  is 2-aminopyrimidine, Sal is a salicylate ion)  in vivo  in mice

M. A. Orlova; T. P. Trofimova; G. Yu. Aleshin; S. S. Belyshev; A. P. Orlov

doi:10.1007/s11172-018-2254-9

The distribution of complexes ^69mZnL¹Cl₂, [^69mZn(L²)₂]Cl₂, and [^69mZn(L²)₂]Sal₂ (L¹ is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide, L² is 2-aminopyrimidine, Sal is a salicylate ion) in vivo in mice

Авторлар: Orlova M.A.¹^,2, Trofimova T.P.¹^,3, Aleshin G.Y.¹, Belyshev S.S.⁴, Orlov A.P.¹
Мекемелер:
1. Department of Chemistry, M. V. Lomonosov Moscow State University
2. D. Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology
3. Institute of Physiologically Active Compounds, Russian Academy of Sciences
4. Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University
Шығарылым: Том 67, № 8 (2018)
Беттер: 1542-1543
Бөлім: Article
URL: https://bakhtiniada.ru/1066-5285/article/view/242920
DOI: https://doi.org/10.1007/s11172-018-2254-9
ID: 242920

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Аннотация

The distribution of complexes of thiazine and pyrimidine derivatives possessing antileukemic activity and labeled with radionuclide ^69mZn in the organs of mice and its rate of excretion were studied. A solution of ZnCl₂ was used for comparison. An increase in the time of excretion of the drug from the body and a decrease of its penetration into the brain in the presence of a salicylate ion were observed.

Авторлар туралы

M. Orlova

Department of Chemistry, M. V. Lomonosov Moscow State University; D. Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology

Хат алмасуға жауапты Автор.
Email: orlova.radiochem@mail.ru
Ресей, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 ul. Samory Mashela, Moscow, 117997

T. Trofimova

Department of Chemistry, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences

Email: orlova.radiochem@mail.ru
Ресей, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432

G. Aleshin

Department of Chemistry, M. V. Lomonosov Moscow State University

Email: orlova.radiochem@mail.ru
Ресей, Build. 3, 1 Leninskie Gory, Moscow, 119991

S. Belyshev

Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University

Email: orlova.radiochem@mail.ru
Ресей, Build. 19, 1 Leninskie Gory, Moscow, 119991

A. Orlov