Email this article The distribution of complexes 69mZnL1Cl2, [69mZn(L2)2]Cl2, and [69mZn(L2)2]Sal2 (L1 is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide, L2 is 2-aminopyrimidine, Sal is a salicylate ion) in vivo in mice
- Authors: Orlova M.A.1,2, Trofimova T.P.1,3, Aleshin G.Y.1, Belyshev S.S.4, Orlov A.P.1
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Affiliations:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- D. Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University
- Issue: Vol 67, No 8 (2018)
- Pages: 1542-1543
- Section: Article
- URL: https://bakhtiniada.ru/1066-5285/article/view/242920
- DOI: https://doi.org/10.1007/s11172-018-2254-9
- ID: 242920
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Abstract
The distribution of complexes of thiazine and pyrimidine derivatives possessing antileukemic activity and labeled with radionuclide 69mZn in the organs of mice and its rate of excretion were studied. A solution of ZnCl2 was used for comparison. An increase in the time of excretion of the drug from the body and a decrease of its penetration into the brain in the presence of a salicylate ion were observed.
About the authors
M. A. Orlova
Department of Chemistry, M. V. Lomonosov Moscow State University; D. Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology
Author for correspondence.
Email: orlova.radiochem@mail.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 ul. Samory Mashela, Moscow, 117997
T. P. Trofimova
Department of Chemistry, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: orlova.radiochem@mail.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432
G. Yu. Aleshin
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991
S. S. Belyshev
Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Russian Federation, Build. 19, 1 Leninskie Gory, Moscow, 119991
A. P. Orlov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991
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