Мақаланы E-mail арқылы жіберу The distribution of complexes 69mZnL1Cl2, [69mZn(L2)2]Cl2, and [69mZn(L2)2]Sal2 (L1 is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide, L2 is 2-aminopyrimidine, Sal is a salicylate ion) in vivo in mice
- Авторлар: Orlova M.A.1,2, Trofimova T.P.1,3, Aleshin G.Y.1, Belyshev S.S.4, Orlov A.P.1
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Мекемелер:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- D. Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University
- Шығарылым: Том 67, № 8 (2018)
- Беттер: 1542-1543
- Бөлім: Article
- URL: https://bakhtiniada.ru/1066-5285/article/view/242920
- DOI: https://doi.org/10.1007/s11172-018-2254-9
- ID: 242920
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
The distribution of complexes of thiazine and pyrimidine derivatives possessing antileukemic activity and labeled with radionuclide 69mZn in the organs of mice and its rate of excretion were studied. A solution of ZnCl2 was used for comparison. An increase in the time of excretion of the drug from the body and a decrease of its penetration into the brain in the presence of a salicylate ion were observed.
Авторлар туралы
M. Orlova
Department of Chemistry, M. V. Lomonosov Moscow State University; D. Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology
Хат алмасуға жауапты Автор.
Email: orlova.radiochem@mail.ru
Ресей, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 ul. Samory Mashela, Moscow, 117997
T. Trofimova
Department of Chemistry, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: orlova.radiochem@mail.ru
Ресей, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 Severnyi pr-d, Chernogolovka, Moscow Region, 142432
G. Aleshin
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Ресей, Build. 3, 1 Leninskie Gory, Moscow, 119991
S. Belyshev
Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Ресей, Build. 19, 1 Leninskie Gory, Moscow, 119991
A. Orlov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Ресей, Build. 3, 1 Leninskie Gory, Moscow, 119991
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