PECULIARITIES OF IMMUNE RESPONSE TO MEASLES VACCINATION IN SERONEGATIVE ADULTS
- 作者: Smerdova M.A.1, Andreev Y.Y.1, Toptygina A.P.1
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隶属关系:
- G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 1021-1023
- 栏目: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/120248
- DOI: https://doi.org/10.31857/S102872210006485-8
- ID: 120248
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全文:
详细
100 healthy adults aged 18–30 years were examined for the presence of measles immunity. A protective level of measles antibodies was found in 32%, and in 68% of adults such antibodies were not detected. Specific cellular immunity to measles virus antigens was detected in 57.37% of the examined individuals, in 26.07% of them specific cellular immunity to measles viruses was not detected, and in 6.56% the response was regarded as equivocal. Seronegative adults were vaccinated with measles cultural live vaccine (“Vector”, Russia). After 6 weeks, protective levels of anti-measles antibodies were detected in all vaccinated patients, the average level was 2.18 (1.40‒3.68) IU/ml. Specific cellular immunity to antigens of measles viruses in 3 people was regarded as equivocal, in the rest of the vaccinated as positive.
作者简介
M. Smerdova
G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
PhD Student, Laboratory of Cytokines,
Moscow
俄罗斯联邦Yu. Andreev
G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
PhD Student, Laboratory of Cytokines,
Moscow
俄罗斯联邦A. Toptygina
G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
编辑信件的主要联系方式.
Email: toptyginaanna@rambler.ru
PhD, MD (Medicine), Leading Research Associate, Laboratory of Cytokines,
Moscow
俄罗斯联邦参考
- Filia A., Bella A., Del Manso M., Baggieri M., Magurano F., Rota M. C. Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 – what is making elimination so difficult? Euro Surveill, 2017, 22(37), 30614.
- Топтыгина А. П., Смердова М. А., Наумова М. А., Владимирова Н. П., Мамаева Т. А. Влияние особенностей популяционного иммунитета на структуру заболеваемости корью и краснухой. Инфекция и иммунитет, 2018, 8(3), 341–348.
- Топтыгина А. П., Семикина Е. Л., Алешкин В. А. Формирование и поддержание специфического клеточного ответа на вакцинацию «Приорикс». Иммунология, 2013, 34(5), 257–261.
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