PECULIARITIES OF IMMUNE RESPONSE TO MEASLES VACCINATION IN SERONEGATIVE ADULTS
- Authors: Smerdova M.A.1, Andreev Y.Y.1, Toptygina A.P.1
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Affiliations:
- G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
- Issue: Vol 22, No 2-2 (2019)
- Pages: 1021-1023
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/120248
- DOI: https://doi.org/10.31857/S102872210006485-8
- ID: 120248
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Abstract
100 healthy adults aged 18–30 years were examined for the presence of measles immunity. A protective level of measles antibodies was found in 32%, and in 68% of adults such antibodies were not detected. Specific cellular immunity to measles virus antigens was detected in 57.37% of the examined individuals, in 26.07% of them specific cellular immunity to measles viruses was not detected, and in 6.56% the response was regarded as equivocal. Seronegative adults were vaccinated with measles cultural live vaccine (“Vector”, Russia). After 6 weeks, protective levels of anti-measles antibodies were detected in all vaccinated patients, the average level was 2.18 (1.40‒3.68) IU/ml. Specific cellular immunity to antigens of measles viruses in 3 people was regarded as equivocal, in the rest of the vaccinated as positive.
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About the authors
M. A. Smerdova
G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
PhD Student, Laboratory of Cytokines,
Moscow
Russian FederationYu. Yu. Andreev
G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
PhD Student, Laboratory of Cytokines,
Moscow
Russian FederationA. P. Toptygina
G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
Author for correspondence.
Email: toptyginaanna@rambler.ru
PhD, MD (Medicine), Leading Research Associate, Laboratory of Cytokines,
Moscow
Russian FederationReferences
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