PECULIARITIES OF IMMUNE RESPONSE TO MEASLES VACCINATION IN SERONEGATIVE ADULTS
- Authors: Smerdova M.A.1, Andreev Y.Y.1, Toptygina A.P.1
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Affiliations:
- G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
- Issue: Vol 22, No 2-2 (2019)
- Pages: 1021-1023
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/120248
- DOI: https://doi.org/10.31857/S102872210006485-8
- ID: 120248
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Abstract
100 healthy adults aged 18–30 years were examined for the presence of measles immunity. A protective level of measles antibodies was found in 32%, and in 68% of adults such antibodies were not detected. Specific cellular immunity to measles virus antigens was detected in 57.37% of the examined individuals, in 26.07% of them specific cellular immunity to measles viruses was not detected, and in 6.56% the response was regarded as equivocal. Seronegative adults were vaccinated with measles cultural live vaccine (“Vector”, Russia). After 6 weeks, protective levels of anti-measles antibodies were detected in all vaccinated patients, the average level was 2.18 (1.40‒3.68) IU/ml. Specific cellular immunity to antigens of measles viruses in 3 people was regarded as equivocal, in the rest of the vaccinated as positive.
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About the authors
M. A. Smerdova
G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
Email: fake@neicon.ru
PhD Student, Laboratory of Cytokines,
Moscow
Russian FederationYu. Yu. Andreev
G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
Email: fake@neicon.ru
PhD Student, Laboratory of Cytokines,
Moscow
Russian FederationA. P. Toptygina
G. N. Gabrichevsky Research Institute for Epidemiology and Microbiology
Author for correspondence.
Email: toptyginaanna@rambler.ru
PhD, MD (Medicine), Leading Research Associate, Laboratory of Cytokines,
Moscow
Russian FederationReferences
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