Intermolecular interactions in rifabutin–2-hydroxypropyl-β-cyclodextrin–water solutions, according to solubility data
- Авторы: Anshakova A.V.1,2, Vinogradov E.V.3, Sedush N.G.4, Kurtikyan T.S.5, Zhokhov S.S.6, Polshakov V.I.6, Ermolenko Y.V.1,2, Konyukhov V.Y.2, Maksimenko O.O.1, Gelperin S.E.1
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Учреждения:
- Nanosystem LTD
- Mendeleev University of Chemical Technology
- National Research Council
- National Research Centre “Kurchatov Institute,”
- Molecular Structure Research Center
- Department of Chemistry
- Выпуск: Том 90, № 5 (2016)
- Страницы: 983-989
- Раздел: Physical Chemistry of Solutions
- URL: https://bakhtiniada.ru/0036-0244/article/view/168168
- DOI: https://doi.org/10.1134/S0036024416050058
- ID: 168168
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Аннотация
The formulations of rifabutin (RB) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), obtained using different preparation techniques, are studied by means of differential scanning calorimetry and molecular spectroscopy (FTIR, NMR, Raman scattering, and photon correlation light scattering). It is established that molecules of RB do not form inclusion complexes with the molecules of HP-β-CD, and an increase in the solubility of RB determined earlier is caused by the formation of weak intermolecular associates.
Об авторах
A. Anshakova
Nanosystem LTD; Mendeleev University of Chemical Technology
Автор, ответственный за переписку.
Email: anshakova_a@mail.ru
Россия, Moscow, 115193; Moscow, 125047
E. Vinogradov
National Research Council
Email: anshakova_a@mail.ru
Канада, Ottawa, ON, K1A 0R6
N. Sedush
National Research Centre “Kurchatov Institute,”
Email: anshakova_a@mail.ru
Россия, Moscow, 123098
T. Kurtikyan
Molecular Structure Research Center
Email: anshakova_a@mail.ru
Армения, Yerevan, 0014
S. Zhokhov
Department of Chemistry
Email: anshakova_a@mail.ru
Россия, Moscow, 119991
V. Polshakov
Department of Chemistry
Email: anshakova_a@mail.ru
Россия, Moscow, 119991
Yu. Ermolenko
Nanosystem LTD; Mendeleev University of Chemical Technology
Email: anshakova_a@mail.ru
Россия, Moscow, 115193; Moscow, 125047
V. Konyukhov
Mendeleev University of Chemical Technology
Email: anshakova_a@mail.ru
Россия, Moscow, 125047
O. Maksimenko
Nanosystem LTD
Email: anshakova_a@mail.ru
Россия, Moscow, 115193
S. Gelperin
Nanosystem LTD
Email: anshakova_a@mail.ru
Россия, Moscow, 115193
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