干细胞对肝硬化模型背景下肝组织功能状态的影响(实验研究)
- 作者: Kotkas I.Е.1, Mazurov V.I.2
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隶属关系:
- North-Western State Medical University named after I.I. Mechnikov
- North-Western State Medical University named after I.I. Mechnikov,
- 期: 卷 12, 编号 4 (2020)
- 页面: 25-32
- 栏目: Original research
- URL: https://bakhtiniada.ru/vszgmu/article/view/43911
- DOI: https://doi.org/10.17816/mechnikov43911
- ID: 43911
如何引用文章
详细
研究现实性。肝硬化的治疗是现代医学的一个极其重要的问题。这类患者的肝功能改善不仅对肝脏学很重要,而且对外科手术也很重要,因为有这种病理的肝脏手术干预往往伴随着肝功能衰竭的发展。
目的是通过实验来评估细胞治疗对肝功能的影响。
材料与方法。这篇文章提出了在模拟肝硬化中使用干细胞的实验研究结果。该实验在132只雌性C57black小鼠身上进行。小鼠的年龄在12到18周之间。在形成肝硬化模型后,为了评估细胞治疗对肝组织功能的影响,干细胞通过周围床血管和门静脉注射入个体。细胞治疗30天后,对受试者的丙氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶、血浆超氧化物歧化酶和谷胱甘肽过氧化物酶活性、血浆二烯结合物水平和血浆丙二醛进行评估。
结果。研究发现,以模拟肝硬化为背景的细胞治疗可降低溶细胞和淤胆综合征的严重程度,刺激肝脏蛋白功能,抑制自由基氧化和刺激抗氧化系统。同时,不将细胞结构引入周围血管,直接引入肝脏血管床时效果最好。
关键词
作者简介
Inna Kotkas
North-Western State Medical University named after I.I. Mechnikov
编辑信件的主要联系方式.
Email: inna.kotkas@yandex.ru
ORCID iD: 0000-0003-4605-9887
SPIN 代码: 1853-8825
зав. хирургическим отделением, к.м.н., доцент кафедры факультетской хирургии им. И. И. Грекова
俄罗斯联邦, Saint PetersburgVadim Mazurov
North-Western State Medical University named after I.I. Mechnikov,
Email: maz.nwgmu@yandex.ru
ORCID iD: 0000-0002-0797-2051
SPIN 代码: 6823-5482
Scopus 作者 ID: 16936315400
head of the department of therapy, rheumatology, examination of temporary disability and the quality of medical care. E.E. Eichwald, w.s. RF, Academician of the Russian Academy of Sciences, MD Professor
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