Markers of endothelial dysfunction in bronchial asthma patients
- 作者: De Silva NM1, Nemtsov VI1, Trofimov VI1
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隶属关系:
- First pavlov State Medical University
- 期: 卷 12, 编号 2 (2015)
- 页面: 15-18
- 栏目: Articles
- URL: https://bakhtiniada.ru/raj/article/view/120767
- DOI: https://doi.org/10.36691/RJA438
- ID: 120767
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详细
Objective. To identify endothelial dysfunction (ED) in patients with bronchial asthma (BA) in the acute phase, to establish the relationship between levels of homocysteine (HC) and endothelin-1 (ET-1) in the blood, and the causes of the disease. Materials and methods. 32 young patients in acute phases of bronchial asthma divided into three groups depending on the cause of bronchial asthma, and 10 healthy individuals were included in the study. Respiratory function assessed by spirometry with bronchodilatation test, serum endothelin-1 level was determined with immunofermental analysis, homocysteine level was determined with plasma liquid chromatography method. The results. There was a significant statistical difference between groups in terms of homocysteine, endothelin-1 levels in blood. Significant positive correlation between the levels of homocysteine and endothelin-1 in patients with allergic bronchial asthma and a significant negative correlation between the marker levels of endothelial dysfunction and lung function were identified. Conclusion. Acute phase of asthma accompanied by endothelial dysfunction, characterized by different levels of homocysteine and endothelin-1 in blood, depending on the genesis of the disease.
作者简介
N De Silva
First pavlov State Medical University
Email: tawa17mnm@yandex.ru
V Nemtsov
First pavlov State Medical University
V Trofimov
First pavlov State Medical University
参考
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