IgE-AB to animals molecular allergens in patients with respiratory allergy
- Authors: Mokronosova MA1, Bass EA1, Bala AM2, Zheltikova TM1
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Affiliations:
- Mechnikov’s Research Institute for Vaccines and Sera, Russian Academy of Medical Sciences
- Helix Laboratory Service
- Issue: Vol 12, No 2 (2015)
- Pages: 25-28
- Section: Articles
- URL: https://bakhtiniada.ru/raj/article/view/120783
- DOI: https://doi.org/10.36691/RJA446
- ID: 120783
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Abstract
Background. The purpose of this study was to identify IgE-antibodies to the major and minor allergenic components of pets in the blood serum of patients with bronchial asthma and/or allergic rhinitis (BA/AR). Methods. The study included 327 patients from Moscow and St. Petersburg. All of them were detected for specific IgE-antibodies (IgE-AB) to the animal allergens by ImmunoCAP® (ThermoFisherScientific, Sweden). 105 patients wanted to detect IgE-AB to the main animal allergens molecules ImmunoCAP ISAC® (ThermoFisherScientific, Sweden). Results. In the sera of 327 patients IgE-AB to cat’s (62%) allergen dominated. IgE-antibodies to dog’s, house dust mites (D.pteronyssinus, D. farinae), mold fungi, horses and rodents allergens were found in 2,6-31 times less. IgE-AB to uteroglobin (rFel d 1), major cat allergen, was detected in 80% of patients (84/105). The detection rate of IgE-AB to other cat allergens was 4,2-8 times lower (rFel d 2 - 10%, nFel d 4 - 19%). IgE-AB to major dog allergen rCan f 1 was detected in 39% of patients (41/105). Positive level of IgE-AB to other dog allergens was detected in 2,2-4,9 times lower (rCan f 2 - 8%, nCan f 3 - 9%, rCan f 5 - 18%). Positive level of IgE-AB to lipocalin was assayed in 6% of patients, to serum albumin - in 7%. Conclusion. Prevalence of IgE-AB to cat and dog allergens was almost 3 times higher than the frequency of detection of IgE-AB to house dust mite allergens in citizens of Moscow and S. Petersburg. The frequency of IgE-AB to rFel d 1 was dominated and detected 2 and 4-11 times often than to rCan f 1 and other animal allergens consequently.
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##article.viewOnOriginalSite##About the authors
M A Mokronosova
Mechnikov’s Research Institute for Vaccines and Sera, Russian Academy of Medical Sciences
E A Bass
Mechnikov’s Research Institute for Vaccines and Sera, Russian Academy of Medical Sciences
A M Bala
Helix Laboratory ServiceSt. Petersburg, Russia
T M Zheltikova
Mechnikov’s Research Institute for Vaccines and Sera, Russian Academy of Medical Sciences
Email: t-zheltikova@yandex.ru
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