电邮这篇文章 A study of osteoprotective effect of l-arginine, l-norvaline and rosuvastatin on a model of hypoestrogen-induced osteoporosis in rats
- 作者: Gudyrev O.S.1, Faitelson A.V.2, Sobolev M.S.2, Pokrovskiy M.V.1, Pokrovskaya T.G.1, Korokin M.V.1, Povetka E.E.1, Miller E.S.1, Soldatov V.O.1
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隶属关系:
- Belgorod State National Research University
- Kursk State Medical University
- 期: 卷 27, 编号 3 (2019)
- 页面: 325-332
- 栏目: Original study
- URL: https://bakhtiniada.ru/pavlovj/article/view/16340
- DOI: https://doi.org/10.23888/PAVLOVJ2019273325-332
- ID: 16340
如何引用文章
详细
Effect on the microcirculatory bed of the bony tissue is one of promising approaches to treatment of osteoporosis.
Aim. To study anti-osteoporotic properties of endothelioprotectors: L-arginine, L-norvaline and rosuvastatin.
Materials and Methods. Osteoprotective properties of L-arginine, L-norvaline and rosuvastatin, and also of a reference drug– strontium ranelate – were studied on 152 female rats of Wistar line using a model of hypoestrogen-induced osteoporosis. Anti-osteoporotic and endothelioprotective effect of the drugs were evaluated by laser dopplerflowmetry (LDF) of the proximal metaphysis of the femoral bone, morphometry of trabeculae of bone, and also by calculation of the coefficient of endothelial dysfunction.
Results. LDF showed that maximal increase in microcirculation of the proximal metaphysis of the femoral bone, in comparison with animals with untreated osteoporosis (61.52±3.74 perfusion units, PU) was achieved with L-norvaline (115.25±5.36 PU, p<0.001) and rosuvastatin (106.57±5.22 PU, p<0.001), less expressed effect was demonstrated by L-arginine (98.10±4.48 PU, p<0.001) and a reference drug – strontium ranelate (86.49±4.99 PU). A similar tendency was observed in morphometry of trabeculae of bone: in the group with untreated osteoporosis the diameter of trabeculae was 61.68±1.24 µm, in the group with use fL-norvaline – 91.86±1.8 µm (p<0.001), in the group with use of L-arginine – 86.64±1.39 µm (p<0.001) and in the group with use of strontium ranelate – 89.08±1.09 µm.
Conclusion. L-arginine and L-norvaline and also rosuvastatin possess the property of improving a morphofunctional condition of bone tissue and may be recommended for further preclinical study.
作者简介
Oleg Gudyrev
Belgorod State National Research University
编辑信件的主要联系方式.
Email: gudyrev@bsu.edu.ru
ORCID iD: 0000-0003-0097-000X
SPIN 代码: 5936-4774
Researcher ID: N-5527-2016
MD, PhD, Associate Professor, Associate Professor of the Department of Pharmacology and Clinical Pharmacology
俄罗斯联邦, BelgorodAleksandr Faitelson
Kursk State Medical University
Email: gudyrev@bsu.edu.ru
ORCID iD: 0000-0003-3759-6373
SPIN 代码: 7389-8181
Researcher ID: A-9809-2017
MD, PhD, Associate Professor, Professor of the Department of Traumatology and Orthopedics
俄罗斯联邦, KurskMikhail Sobolev
Kursk State Medical University
Email: gudyrev@bsu.edu.ru
ORCID iD: 0000-0001-7839-2049
SPIN 代码: 2987-3470
Researcher ID: A-9473-2019
PhD-Student of the Department of Traumatology and Orthopedics
俄罗斯联邦, KurskMikhail Pokrovskiy
Belgorod State National Research University
Email: gudyrev@bsu.edu.ru
ORCID iD: 0000-0002-1493-3376
SPIN 代码: 9201-3580
Researcher ID: A-4427-2017
MD, PhD, Professor, Head of the Department of Pharmacology and Clinical Pharmacology
俄罗斯联邦, BelgorodTat`yana Pokrovskaya
Belgorod State National Research University
Email: gudyrev@bsu.edu.ru
ORCID iD: 0000-0001-6802-5368
SPIN 代码: 8338-0100
Researcher ID: A-5281-2017
MD, PhD, Professor, Professor of the Department of Pharmacology and Clinical Pharmacology
俄罗斯联邦, BelgorodMikhail Korokin
Belgorod State National Research University
Email: gudyrev@bsu.edu.ru
ORCID iD: 0000-0001-5402-0697
SPIN 代码: 8385-3508
Researcher ID: A-6652-2017
MD, PhD, Professor, Professor of the Department of Pharmacology and Clinical Pharmacology
俄罗斯联邦, BelgorodElena Povetka
Belgorod State National Research University
Email: gudyrev@bsu.edu.ru
ORCID iD: 0000-0003-4517-1041
SPIN 代码: 3609-4411
Researcher ID: A-8035-2019
Student
俄罗斯联邦, BelgorodEduard Miller
Belgorod State National Research University
Email: gudyrev@bsu.edu.ru
ORCID iD: 0000-0001-7982-7518
SPIN 代码: 8028-5617
Researcher ID: A-7578-2019
Student
俄罗斯联邦, BelgorodVladislav Soldatov
Belgorod State National Research University
Email: gudyrev@bsu.edu.ru
ORCID iD: 0000-0001-9706-0699
SPIN 代码: 8763-8217
Researcher ID: A-7292-2019
Assistant of the Department of Pharmacology and Clinical Pharmacology
俄罗斯联邦, Belgorod参考
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