电邮这篇文章 Prognostic significance of degree histologically malignant ductal pancreatic adenocarcinoma
- 期: 卷 21, 编号 4 (2013)
- 页面: 117-127
- 栏目: Articles
- URL: https://bakhtiniada.ru/pavlovj/article/view/4563
- DOI: https://doi.org/10.17816/PAVLOVJ20134117-127
- ID: 4563
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The article presents the results of a study of 47 patients (22 males and 25 females) PAK prostate treated at Institute of Surgery. A.V. Vishnevsky from 2005 to 2012. The age of patients ranged from 47 to 76 years, mean age was 60 years. In 24 patients at the time of surgery was diagnosed IIb (pT2- 3, N1) tumor stage, 19 - IIa (pT2-3, N0), have 3 -III (pT4), from 1 - Ib (pT2, N0). In 27 observations revealed metastases to regional lymph nodes (N1). Staging was performed according to the revision of the International Classification of 7 TNM (UICC, 2010). The results also show that such clinical and morphological characteristics as gender, patient age, stage and tumor size did not affect the postoperative survival. No significant correlation between patient survival and tumor grade (grade), determined by the degree of differentiation, as recommended by WHO. In contrast, when using the Gleason system, which takes into account not only the most abundant component in the tumor, but also the second most common, obtained a significant correlation with postoperative survival rates, making this a promising grading system for use in the diagnosis of ductal adenocarcinoma of the pancreas.
参考
- Давыдов М.И. Статистика злокачественных новообразований в России и странах СНГ в 2010 г / М.И. Давыдов, Е.М. Аксель. - М., 2012.
- Отдаленные результаты лечения протоковой аденокарциномы головки поджелудочной железы: факторы, влияющие на прогноз течения заболевания / В.А. Кубышкин [и др.] // Анналы хирургической гепатологии. - 2004. -Т. 9, №1. - С. 129-133.
- Патютко Е.И. Хирургия рака органов билиопанкреатодуоденальной зоны / Е.И. Патютко, А.Г. Котельников. - М. : Медицина, 2007.
- A proposal for a new and more practical grading scheme for pancreatic ductal adenocarcinoma / N.V. Adsay [et al.] // Am J Surg Pathol. - 2005. - Vol. 29, №6. - P. 724-33.
- Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas / D. Alderson [et al.] // Gut. - 2005. - Vol. 54 (Suppl. 5). - P. 1-16.
- World Health Organization international histological classification of tumors of the Digestive System / F.T. Bosman [et al.]. -4th ed. - Lion, 2010.
- Esposito I. Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer Resections / I. Esposito, A.M. Schlitter // Cancers. - 2010. - Vol. 2. -P. 2001-2010.
- Ghaneh P. Biology and management of pancreatic cancer / P. Ghaneh, E. Costello, J. Neoptolemus // Gut. - 2007. - Vol. 56, №8. - P. 1134-1152.
- Gleason D. Classification of prostate carcinomas / D. Gleason // Cancer Chemother. - 1966. - Vol. 50. - P. 125-128.
- The grade of pancreatic ductal carcinomas is an independent prognostic factor and is superior to the immunohistochemical assessment of proliferation / J. Luttges [et al.] // J Pathol. - 2000. - Vol. 191. -P. 154-161.
- Navas C. 3EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma / C. Navas, I. Hemandez-Porras, A.J. Schuhmacher // Cancer cell. - 2012. -Vol. 22, № 3. - P. 318.
- Molecular Pathology of Primary and Metastatic Ductal Pancreatic Lessions / B.A. Rugerri [et al.] // Cancer. - 1997. -Vol. 40. - P. 418.
- Pancreatic cancer: basic and clinical aspects / F. Eckel [et al.] // Gastroenterology. - 2005. - Suppl.128. - P. 1606-1625.
- Anaplastic pancreatic cancer: Presentation, surgical management, and outcome / O. Strobel [et al.] // Surgery. - 2011. -Vol. 149, № 2. - P. 200-208.
- Nuclear DNA distribution pattern of the parenchymal cells in adenocarcinomas of the pancreas and in chronic pancreatitis. A study of archival specimens using both image and flowcytometry / A.R. Weger [et al.] // Gastroenterology. - 1990. - Vol. 99. - P. 237-242.
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