Autoantibodies to activated blood coagulation factors in patients with ischemic heart disease

Aim. To study the content of autoantibodies to activated blood coagulation factors IIa, VIIa and IXa during ischemic heart disease. Methods. The investigation of autoantibodies was performed in 31 patients (mean age 57.6±7.8 years, male to female ratio 4:1). The patients were divided into three groups: the first - patients with myocardial infarction in the acute stage (9 people), the second - patients with myocardial infarction in the subacute stage (9 people), the third - patients with stable angina (13 people). The control group included 18 practically healthy subjects comparable by age and sex. The study of the content of autoantibodies to blood coagulation factors was performed by an original immunoassay method of Tsybikova N.N. et al. Results. Established was a decrease in the content of the following autoantibodies: class M immunoglobulins to fac-tor VIIa, class G immunoglobulins - to factor VIIa, classes M and G immunoglobulins - to factor IXa in the acute phase of myocardial infarction compared with the controls, as well as a decrease in the content of class G immunoglobulins to the factor IXa in the acute stage of myocardial infarction compared with the subacute stage and stable angina. Conclusion. During ischemic heart disease a decrease in the content of autoantibodies to the activated blood coagulation factors IIa, VIIa and IXa occurs, which is presumably due to their binding with excessively formed activated coagulations factors.

autoantibodies, blood coagulation factors, hemostasis, ischemic heart disease