Effect of pyrimidine derivatives: Xymedone and diuciphone on bioenergetic processes of mitochondria
- Authors: Slabnov Y.D.1,2, Valimukhametova D.A.1,2, Valeeva I.K.1,2, Garaev R.S.1,2
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Affiliations:
- Republican Medical Diagnostic Center, Ministry of Health of the Republic of Tatarstan
- Kazan State Medical University
- Issue: Vol 77, No 3 (1996)
- Pages: 179-181
- Section: Theoretical and clinical medicine
- URL: https://bakhtiniada.ru/kazanmedj/article/view/104430
- DOI: https://doi.org/10.17816/kazmj104430
- ID: 104430
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Abstract
The stimulation of oxygen consumption in the presence of incubative medium just as excessive quantity of oxidation substrate, so oxidation phosphorylation disconnector of 2,4-dinitrophenol is shown on thymocytes of not pedigree he-rats obtaining xymedone (3 mg/kg and 30 mg/kg) and diuci phone (30 mg/kg) during 9 and 30 days. The effect of xymedone is dosedependent and more pronounced than the effect of diuciphone. The uniform effect of xymedone on mitochondrion respiration of thymocytes and isolated mitochondria of the liver is shown.
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##article.viewOnOriginalSite##About the authors
Yu. D. Slabnov
Republican Medical Diagnostic Center, Ministry of Health of the Republic of Tatarstan; Kazan State Medical University
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Kazan; Kazan
D. A. Valimukhametova
Republican Medical Diagnostic Center, Ministry of Health of the Republic of Tatarstan; Kazan State Medical University
Email: info@eco-vector.com
Russian Federation, Kazan; Kazan
I. Kh. Valeeva
Republican Medical Diagnostic Center, Ministry of Health of the Republic of Tatarstan; Kazan State Medical University
Email: info@eco-vector.com
Russian Federation, Kazan; Kazan
R. S. Garaev
Republican Medical Diagnostic Center, Ministry of Health of the Republic of Tatarstan; Kazan State Medical University
Email: info@eco-vector.com
Russian Federation, Kazan; Kazan
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