Email this article The value of vaginal lactobacilli in the restoration of vaginal microbiocenosis in women in the early postpartum period, depending on the method of delivery
- Authors: Dadayeva D.G.1, Budilovskaya O.V.2,3, Krysanova A.A.2,3, Khusnutdinova T.A.4, Savicheva A.M.2,3, Kogan I.Y.5
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Affiliations:
- The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
- Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
- Saint Petersburg State Pediatric Medical University
- Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott, Saint Petersburg State Pediatric Medical University
- Saint Petersburg State University
- Issue: Vol 70, No 4 (2021)
- Pages: 15-23
- Section: Original study articles
- URL: https://bakhtiniada.ru/jowd/article/view/66711
- DOI: https://doi.org/10.17816/JOWD66711
- ID: 66711
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Abstract
BACKGROUND: Despite numerous studies of the vaginal microbiota, there is still a lack of knowledge regarding its restoring dynamics in the early postpartum period. The condition of the vaginal microflora during pregnancy plays a key role in maintaining the physiological microbiocenosis of the birth canal and creating conditions for the normal course of pregnancy, the establishment of an infant’s intestinal microbiota, and the further development of the child.
AIM: The aim of this study was to estimate the role of certain types of lactobacilli in restoring the vaginal microbiota in women in the early postpartum period, depending on the method of delivery.
MATERIALS AND METHODS: We examined 150 women at 38-41 weeks of gestation. The clinical material for the study was vaginal discharge before and after delivery. To determine the species of lactobacilli and other microorganisms in the clinical material, we used quantitative real-time PCR.
RESULTS: Before delivery, lactobacilli were found in vaginal discharge in 144 out of 150 women (96.0%), their number in the majority being more than 106 GE. In the postpartum period, lactobacilli were found in 66/128 (51.5%) cases, while prevailing in women after vaginal delivery in 50/65 (76.9%) cases (4.6±1.6, p = 0.000000). Among the dominant species of lactobacilli was L. crispatus, found in vaginal discharge before delivery, which most often affects the recovery of the vaginal microbiota in the postpartum period (29 out of 61 women, 47.5%). L. iners detected in the lochia predisposes to the violation of uterine involution in the early postpartum period (p = 0.03).
CONCLUSIONS: Normal vaginal microbiota in the postpartum period is restored more quickly in women after vaginal delivery. Our study confirms that L. crispatus and L. iners play a major role in restoring the vaginal microbiota in the postpartum period.
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##article.viewOnOriginalSite##About the authors
Dzhamilya G. Dadayeva
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: djamilya2010@mail.ru
ORCID iD: 0000-0002-1190-0149
MD, Post-Graduate Student
Russian Federation, 3 Mendeleevskaya Line, Saint Petersburg, 199034Olga V. Budilovskaya
Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University
Email: o.budilovskaya@gmail.com
ORCID iD: 0000-0001-7673-6274
SPIN-code: 7603-6982
MD, Researcher, The Laboratory of Microbiology
Russian Federation, 3 Mendeleevskaya Line, Saint Petersburg, 199034; Saint PetersburgAnna A. Krysanova
Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University
Email: krusanova.anna@mail.ru
ORCID iD: 0000-0003-4798-1881
SPIN-code: 2438-0230
MD, Researcher, Laboratory of Microbiology, Assistant of the Department of Clinical Laboratory Diagnostics of the Faculty of Postgraduate and Additional Professional Education
Russian Federation, 3 Mendeleevskaya Line, Saint Petersburg, 199034; Saint PetersburgTatyana A. Khusnutdinova
Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott, Saint Petersburg State Pediatric Medical University
Email: HusnutdinovaT@yandex.ru
ORCID iD: 0000-0002-2742-2655
SPIN-code: 9533-9754
Researcher. The Laboratory of Microbiology; Assistant. The Department of Clinical Laboratory Diagnostics, the Faculty of Postgraduate and Additional Professional Education
Russian Federation, 3 Mendeleevskaya Line, Saint Petersburg, 199034; Saint PetersburgAlevtina M. Savicheva
Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University
Email: savitcheva@mail.ru
ORCID iD: 0000-0003-3870-5930
SPIN-code: 8007-2630
Scopus Author ID: 6602838765
MD, Dr. Sci. (Med.), Professor, Honored Scientist of the Russian Federation, Head of the Laboratory of Microbiology, Head of the Department of Clinical Laboratory Diagnostics of the Faculty of Postgraduate and Additional Professional Education
Russian Federation, 3 Mendeleevskaya Line, Saint Petersburg, 199034; Saint PetersburgIgor Y. Kogan
Saint Petersburg State University
Author for correspondence.
Email: ikogan@mail.ru
ORCID iD: 0000-0002-7351-6900
SPIN-code: 6572-6450
Scopus Author ID: 56895765600
MD, Dr. Sci. (Med.), Professor, Corresponding Member of RAS, Director
Russian Federation, Saint PetersburgReferences
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