Combined physical activity in the prevention of cardiovascular diseases: from physiological to molecular adaptation mechanisms

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Abstract

Physical activity is recognized as the most important non-medicinal tool for the prevention of cardiovascular diseases, however, the highest efficiency is demonstrated by the programs combining various types of physical load. The present review summarizes the current scientific data on the effects of combined physical activity, including the aerobic exercises of moderate and high intensity and the muscle strengthening exercises, as well as the ones affecting the system of cardiometabolic regulation. A disclosure is provided for the multi-level adaptation mechanisms, encompassing the physiological, vegetative, hormonal, molecular and epigenetic levels. It was justified that combined training modalities possess the synergetic effects, facilitating the decrease of blood pressure, the increase in the cardiac rhythm variability, the improvement of insulin sensitivity, the decrease of chronic inflammation and the activation of cardioprotective transcription programs. A detailed description was provided for the key molecular pathways participating in the adaptational response (AMP-activated protein kinase, mTOR, PGC-1α, autophagia and the unfolded protein response), as well as the role of exerkines — the signaling molecules produced in response to physical load. Special attention was paid to the epigenetic modifications, including the methylation of DNA, the regulation of microRNA and the telomere stability, as the mechanisms of long-term protection from the cardiovascular diseases. The data provided emphasizes the necessity of introducing the combined modalities of physical activity into the programs of individual and populational prevention. Besides, further research is required on the optimal combination of intensity, extent and patterns of physical load for various population categories for the purpose of maximizing the protective adaptation of the cardiovascular system.

About the authors

Abduragim R. Magomedov

Kuban State Medical University

Author for correspondence.
Email: ktrnkzhvnkv@gmail.com
ORCID iD: 0009-0008-9366-5648
Russian Federation, 4 Mitrofan Sedin st, Krasnodar, 350063

Polina V. Rykova

The Russian National Research Medical University named after N.I. Pirogov

Email: polina.rykova123@yandex.ru
ORCID iD: 0009-0000-5613-0160
Russian Federation, Moscow

Bogdan A. Anokhin

Leader Stom Company

Email: bogdananohin111@gmail.com
ORCID iD: 0009-0000-4512-1621
Russian Federation, Rostov-on-Don

Arthur Kh. Melikian

Astrakhan State Medical University

Email: bibbobbub@mail.ru
ORCID iD: 0009-0003-2690-8148
Russian Federation, Astrakhan

Minas A. Agaronyan

Kuban State Medical University

Email: Minas8434@gmail.com
ORCID iD: 0009-0007-8446-0424
Russian Federation, 4 Mitrofan Sedin st, Krasnodar, 350063

Arina G. Sarkisyan

Kuban State Medical University

Email: sarkisyan.arina@bk.ru
ORCID iD: 0009-0001-4729-3424
Russian Federation, 4 Mitrofan Sedin st, Krasnodar, 350063

Ekaterina S. Shimko

Kuban State Medical University

Email: kateshimko@yandex.ru
ORCID iD: 0009-0008-4748-1362
Russian Federation, 4 Mitrofan Sedin st, Krasnodar, 350063

Ayshat Yu. Yusupova

Astrakhan State Medical University

Email: ayshat.yusupova.01@list.ru
ORCID iD: 0000-0002-6835-5751
Russian Federation, Astrakhan

Elvina R. Irgalieva

Astrakhan State Medical University

Email: elvina.i.r@mail.ru
ORCID iD: 0009-0001-3549-4173
Russian Federation, Astrakhan

Eset M. Bokova

Peoples’ Friendship University of Russia

Email: dalismirnova688@gmail.com
ORCID iD: 0009-0004-0326-0577
Russian Federation, Moscow

Rashid S. Mokaev

Kuban State Medical University

Email: borka22817@gmail.com
ORCID iD: 0009-0003-7849-3853
Russian Federation, 4 Mitrofan Sedin st, Krasnodar, 350063

Darya V. Leonova

Rostov State Medical University

Email: dashadasha101220@mail.ru
ORCID iD: 0009-0003-3697-5782
Russian Federation, Rostov-on-Don

Adil Sh. Kendzhametov

V.I. Vernadsky Crimean Federal University

Email: kendzhametov2016@gmail.com
ORCID iD: 0009-0008-8069-0895
Russian Federation, Simferopol

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