Email this article 
Post a Comment Role of vasculoendothelial growth factor and its gene in pathogenesis of hepatobiliary pathology
- Authors: Schekotova A.P.1, Bulatova I.A.1
-
Affiliations:
- E.A. Vagner Perm State Medical University
- Issue: Vol 37, No 4 (2020)
- Pages: 36-45
- Section: Original studies
- URL: https://bakhtiniada.ru/PMJ/article/view/48967
- DOI: https://doi.org/10.17816/pmj37436-45
- ID: 48967
Cite item
Full Text
Abstract
Objective. To assess the pathogenetic value of vasculoendothelial growth factor (VEGF) and polymorphism of its gene in hepatobiliary pathology.
Materials and methods. The study included 190 patients with hepatobiliary pathology (HBP): 100 patients with chronic hepatitis C (CHC) in the reactivation phase, 50 – with HC in the outcome of CHC, 30 – with cholelithiasis, 10 – with focal liver lesions (including 8 with primary and secondary liver tumors).
Results. In case of hepatobiliary pathology, VEGF, as indicator neoangiogenesis and endothelial dysfunction (ED), is a marker of the severity of liver lesion: its production is increased in some patients with cholelithiasis, moderately elevated in all patients with CH and significantly elevated against the background of HC and liver pathology of the tumor genesis. In chronic diffuse diseases of the liver, there are detected multiple reliable relationships between VEGF and a number of ED indices, hepatic clinical and biochemical syndromes, liver fibrosis markers, viral load level that proves the obligate involvement of VEGF in the development and progression of liver pathology. VEGF can be used as a test for differential diagnosis of fibrosis in CH and HC with the sensibility of 90 % and specificity of 78 %. Carriage of the allele C in the locus of the VEGF gene (G-634C) in the form of homozygote CC can show the risk of more severe lesion of the liver in CHC and is interconnected with increased production of VEGF.
Conclusions. Vasculoendothelial growth factor and polymorphism of its gene is involved in the pathogenesis of hepatobiliary pathology, activating neoangiogenesis and fibrosis in the liver.
Full Text
##article.viewOnOriginalSite##About the authors
A. P. Schekotova
E.A. Vagner Perm State Medical University
Author for correspondence.
Email: al_shchekotova@mail.ru
MD, PhD, Professor, Department of Faculty Therapy №2, Professional Pathology and Clinical Laboratory Diagnostics
Russian Federation, PermI. A. Bulatova
E.A. Vagner Perm State Medical University
Email: al_shchekotova@mail.ru
MD, PhD, Professor, Department of Faculty Therapy №2, Professional Pathology and Clinical Laboratory Diagnostics
Russian Federation, PermReferences
- Ferna´ndez M., Semela D., Bruix J., Colle I., Pinzani M., Bosch M. Angiogenesis in liver disease. Journal of Hepatology 2009; 50: 604–620. doi: 10.1016/j.jhep. 2008.12.011.
- Wynn А. Celluar and Molecular Mechanisms of Fibrosis. J Pathol 2008; 214: 199–210.
- Helaly G.F., Abou Shamaa L.A. Influence of hepatitis C virus infection on circulating levels of sICAM-1 and VEGF in patients with hepatitis C and hepatocellular carcinoma (HCC) and their role in enhancing detection of HCC. Egypt J Immunol 2006; 1 (13); 27–38.
- Shchekotova A.P. Clinical and laboratory indicators and endothelial dysfunction in liver diseases, their diagnostic and prognostic significance and possible use for evaluating the effectiveness of therapy: dis…. doktora med. nauk. Perm' 2012; 224 (in Russian).
- EASL Clinical Practice Guidelines: Management of hepatitis C virus infection. Journal of Hepatology 2014; 60: 392–420.
- Shchekotova A.P., Kotel'nikova L.P., Mugatarov I.N., Fedachuk N.N. Endothelial dysfunction, inflammation and fibrosis in hepatobiliary pathology. Fundamental'nye issledovaniya 2013; 5(2): 451–455 (in Russian).
- Çadırcı K, Keskin H, Okçu N. Vascular Endothelial Growth Factor Levels in Chronic Hepatitis and Liver Cirrhosis Associated with Hepatitis C. Kafkas J Med Sci 2019; 9(2):74–78. DOI: 0.5505/kjms.2019.33340
- Bulatova I.A. Fibrosis in chronic liver diseases: mechanisms of development, clinical and laboratory assessment of progression and monitoring of therapy: avtoref. dis. ... doktora med. nauk. Perm' 2016; 50 (in Russian).
Supplementary files
