Email this article 
Post a Comment Role of connective tissue dysplasia in pathogenesis of diverticular disease
- Authors: Valinurov A.A.1,2, Chernyshova T.E.2, Styazhkina S.N.2
-
Affiliations:
- City Clinical Hospital №7
- Izhevsk State Medical Academy
- Issue: Vol 40, No 4 (2023)
- Pages: 23-30
- Section: Original studies
- URL: https://bakhtiniada.ru/PMJ/article/view/144144
- DOI: https://doi.org/10.17816/pmj40423-30
- ID: 144144
Cite item
Full Text
Abstract
Objectives. To conduct a comparative analysis of the role of connective tissue dysplasia in the development of diverticular disease.
Materials and methods. At the screening stage of a single-stage study, clinical, functional, and radiological predictors of connective tissue dysplasia with diagnosed diverticular disease were evaluated. At the second stage of the study, a colonoscopy was performed. The disease was diagnosed by the combination of phenotypic signs of dysmorphic genesis.
Results. At the first stage, in 82 % of cases patients were concerned about their asthenic syndrome. Thirty-two patients with confirmed connective tissue dysplasia underwent colonoscopy. Diverticular disease was diagnosed in 28 patients (89.6 %).
Conclusions. High comorbidity of patients is associated with genetically determined disorders of connective tissue metabolism, manifested by a high frequency of diverticular formation. With a large number of diagnosed phenes, we can predict a rapid progression of diverticular disease. The frequency and severity are due to changes in the mechanical properties of the connective tissue of the submucosal layer.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
A. A. Valinurov
City Clinical Hospital №7; Izhevsk State Medical Academy
Author for correspondence.
Email: mr-valinurov@yandex.ru
Deputy Chief Physician for Clinical and Experimental Work, postgraduate student of the Department of Faculty Surgery
Russian Federation, Izhevsk; IzhevskT. E. Chernyshova
Izhevsk State Medical Academy
Email: mr-valinurov@yandex.ru
MD, PhD, Professor, Department of General Practice with Courses of Emergency Care
Russian Federation, IzhevskS. N. Styazhkina
Izhevsk State Medical Academy
Email: mr-valinurov@yandex.ru
MD, PhD, Professor, Department of Faculty Surgery
Russian Federation, IzhevskReferences
- Ardatskaya M.D., Achkasov S.I., Veselov V.V., etc. Diverticular disease: clinical recommendations. Coloproctology 2021; 20: 10–27 (in Russian).
- Vorobey A.V., Haji Ismail I.A., Lagodich N.A. et al. Diverticular colon disease: pathogenesis, classification and complications. Medical News 2020; 6 (309): 25–29 (in Russian).
- Nechaeva G.I., Lyalyukova E.A., Rozhkova M.Yu. Connective tissue dysplasia: the main gastroenterological manifestations. Experimental and clinical gastroenterology 2010; 6: 66–69 (in Russian).
- Minushkin O.N., Kruchinina M.A., Altukhova E.I., Yu.E. Tugova Diverticular colon disease: diagnosis, treatment, prevention of complications. Medical Council 2022; 6: 109–115 (in Russian).
- Clinical recommendations of the Russian Scientific Medical Society of Therapists on the diagnosis, treatment and rehabilitation of patients with connective tissue dysplasia (first revision). Medical Bulletin of the North Caucasus 2018; 1,2 (13): 137–210. doi: 10.14300/mnnc.2018.13037 (in Russian).
- Rybachkov V.V., Dryazhenkov I.G., Krasilnikova Z.V. et al. Features of the course of diverticular colon disease. Infections in surgery 2019; 2–3: 30–32 (in Russian).
- Strelkov N.S., Kildiyarova R.R., Sharaev P.N., Ishmametyev I.L. Connective tissue in children with pathology: monograph. Edited by R.R. Kildiyarova. Izhevsk 2011; 210 (in Russian).
- Butolin E.G., Smetanin M.Yu., Druk I.V., Nechaeva G.I., Loginova E., Lyalyukova E.A., Vershinina M.V., Chernyshova T.E., Kononova N.Yu., Styazhkina S.N., Maslova I.S., Kildiyarova R.R. Particular issues of connective tissue dysplasia. Edited by T.E. Chernyshova. Izhevsk 2022; 97 (in Russian).
Supplementary files
