ALTERATIONS IN THE MRNA EXPRESSION OF D2 DOPAMINE RECEPTOR SPLICE VARIANTS AS POSSIBLE MECHANISM OF PREFRONTAL DYSFUNCTION AFTER EARLY-LIFE IMMUNE CHALLENGE
- Authors: Schwarz AP1, Trofimov AN2, Ischenko AM3, Zubareva OE4, Klimenko VM2
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Affiliations:
- Multidisciplinary Laboratory of Neurobiology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg
- Laboratory of Neurobiology of the Brain Integrative Functions, I.P. Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg
- Laboratory of Protein Biochemistry, Research Institute of Highly Pure Biopreparations, Saint Petersburg
- Laboratory of Molecular Mechanisms of Neuronal Interactions, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg
- Issue: Vol 19, No 1S (2019)
- Pages: 109-111
- Section: Articles
- URL: https://bakhtiniada.ru/MAJ/article/view/19352
- ID: 19352
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##article.viewOnOriginalSite##About the authors
A P Schwarz
Multidisciplinary Laboratory of Neurobiology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg
A N Trofimov
Laboratory of Neurobiology of the Brain Integrative Functions, I.P. Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg
A M Ischenko
Laboratory of Protein Biochemistry, Research Institute of Highly Pure Biopreparations, Saint Petersburg
O E Zubareva
Laboratory of Molecular Mechanisms of Neuronal Interactions, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg
V M Klimenko
Laboratory of Neurobiology of the Brain Integrative Functions, I.P. Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg
References
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- Zubareva OE, Shcherbakova KP, Kalemenev SV, et al. Impairments to conditioned reflex activity in adult rats after administration of interleukin-1β during early postnatal ontogeny. Neuroscience and Behavioral Physiology. 2013;43(2):210-213.
- Beaulieu J-M, Espinoza S, Gainetdinov RR. Dopamine receptors - IUPHAR Review 13. British Journal of Pharmacology. 2015;172(1):1-23.
- Zhang Y, Bertolino A, Fazio L, et al. Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc Natl Acad Sci U S A. 2007;104(51):20552-20557.
- Schwarz AP, Rotov AY, Chuprina OI, et al. Developmental prefrontal mRNA expression of D2 dopamine receptor splice variants and working memory impairments in rats after early life Interleukin-1β elevation. Neurobiology of Learning and Memory. 2018;155:231-238.
- Zubareva OE, Eliseeva AP, Simbirtsev AS, Klimenko VM. The effects of proinflammatory cytokines on the formation of behavior in early postnatal ontogenesis. Neuroscience and Behavioral Physiology. 2006;36(4):367-372.
- Schwarz AP, Trofimov AN, Zubareva OE, et al. Prefrontal mRNA expression of long and short isoforms of D2 dopamine receptor: Possible role in delayed learning deficit caused by early life interleukin-1β treatment. Behavioural Brain Research. 2017;333:118-122.
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