Email this article Concentration of essential chemical elements in whole blood and in paranasal sinuses mucosa is related to chronic rhinosinusitis severity in children
- Authors: Alekseenko S.I.1,2,3, Dvoryanchikov V.V.1, Skalny A.V.4,5, Anikin I.A.1,3, Isachenko V.S.6, Tinkov A.A.4,5
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Affiliations:
- St. Petersburg Research Institute of Ear, Throat, Nose and Speech
- North-Western State Medical University named after I.I. Mechnikov
- St. Petersburg Children’s municipal multi-specialty clinical center of high medical technology named after K.A. Rauhfus
- Sechenov First Moscow State Medical University
- RUDN University
- Military Medical Academy named after S.M. Kirov
- Issue: Vol 6, No 4 (2021)
- Pages: 9-13
- Section: ENT Disorders
- URL: https://bakhtiniada.ru/2500-1388/article/view/89448
- DOI: https://doi.org/10.35693/2500-1388-2021-6-4-9-13
- ID: 89448
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Abstract
Objectives – to evaluate the association between essential chemical element levels in whole blood and in pathologic mucosa and chronic rhinosinusitis severity in children.
Material and methods. A total of 154 children aged from 6 to 17 years were examined. Among them, 88 children had chronic rhinosinusitis (CRS) and underwent functional endoscopic sinus surgery (FESS). The 66 healthy children were included in the control group. Life quality was assessed using SNOT-20 (Sino-Nasal Outcome Test-20). Endoscopic and computer tomography findings were evaluated using Lund – Kennedy and Lund – Mackay scales, respectively. The assessment of essential element levels in whole blood samples was performed using inductively-coupled plasma mass-spectrometry.
Results. The obtained data demonstrate that total SNOT-20 scores in CRS patients were 68% higher than in controls. At the same time, whole blood calcium, selenium, zinc, and magnesium levels were 6%, 28%, 20%, and 3% lower than the respective control values. The analysis of pathologic mucosa demonstrated that the chemical element contents were reducing in the following order: Ca > Mg = Fe > Zn > Cu> Mn > Se. However, only whole blood selenium level correlated significantly with its tissue level. In multiple regression models, the whole blood Se level was inversely associated with SNOT-20 and Lund – Mackay total scores.
Conclusion. Therefore, the obtained data allow to propose the potential role of altered calcium, magnesium, zinc and selenium metabolism in CRS progression.
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##article.viewOnOriginalSite##About the authors
Svetlana I. Alekseenko
St. Petersburg Research Institute of Ear, Throat, Nose and Speech; North-Western State Medical University named after I.I. Mechnikov; St. Petersburg Children’s municipal multi-specialty clinical center of high medical technology named after K.A. Rauhfus
Author for correspondence.
Email: svolga-lor@mail.ru
ORCID iD: 0000-0002-3377-8711
PhD, Associate professor, Chief researcher at the Department of high-technology treatment methodology development; Associate professor of the Chair of Otorhinolaryngology; Head of the ENT department
Russian Federation, St. PetersburgVladimir V. Dvoryanchikov
St. Petersburg Research Institute of Ear, Throat, Nose and Speech
Email: v.v.dvoryanchikov@mail.ru
ORCID iD: 0000-0002-0925-7596
PhD, Professor, Director
Russian Federation, St. PetersburgAnatolii V. Skalny
Sechenov First Moscow State Medical University; RUDN University
Email: skalny3@microelements.ru
ORCID iD: 0000-0001-7838-1366
PhD, Professor, Head of the Department of Medical Elementology; Head of the Laboratory of Molecular Dietetics
Russian Federation, MoscowIgor A. Anikin
St. Petersburg Research Institute of Ear, Throat, Nose and Speech; St. Petersburg Children’s municipal multi-specialty clinical center of high medical technology named after K.A. Rauhfus
Email: dr-anikin@mail.ru
ORCID iD: 0000-0003-2977-2656
PhD, Professor; Head of the Department of high-technology treatment methodology development
Russian Federation, St. PetersburgVadim S. Isachenko
Military Medical Academy named after S.M. Kirov
Email: lor_vma@mail.ru
ORCID iD: 0000-0001-9090-0413
PhD, Associate professor of the Chair of Otorhinolaryngology
Russian Federation, St. PetersburgAleksei A. Tinkov
Sechenov First Moscow State Medical University; RUDN University
Email: tinkov.a.a@gmail.com
ORCID iD: 0000-0003-0348-6192
PhD, Associate professor, Department of Medical Elementology; Chief researcher at the Laboratory of Molecular Dietetics
Russian Federation, MoscowReferences
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