Peculiarities of the clinical course of myocardial infarction associated with malignant neoplasms of various stages and localizations at the hospital period
- Authors: Skorodumova E.G.1, Skorodumova E.A.1, Kostenko V.A.1, Siverina A.V.1
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Affiliations:
- I.I. Dzhanelidze Saint Petersburg Research Institute of Emergency Care
- Issue: Vol 10, No 8 (2024)
- Pages: 50-56
- Section: ORIGINAL STUDIES
- URL: https://bakhtiniada.ru/2412-4036/article/view/271111
- DOI: https://doi.org/10.18565/therapy.2024.8.50-56
- ID: 271111
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Abstract
Abstract. Cardiovascular and oncological diseases are the leading causes of fatal outcomes. Due to constantly improving approaches to the management of these pathologies, the prognosis and life expectancy of such patients are improving.
The aim: to identify the peculiarities of myocardial infarction (MI) clinical course in patients with malignant neoplasms (MN) in multidisciplinary hospital conditions.
Material and methods. Medical records of 456 patients treated at I.I. Dzhanelidze research institute of emergency care from 2017 to 2022 with MI associated with MN were processed. Patients were divided into three groups: I – with MI and a history of cancer (n = 162), II – with MI and current oncological process (n = 194), III (control) – with MI without MN (n = 100). Gender, age, presence/absence of ST segment elevation on electrocardiogram (ECG), class of acute heart failure (AHF) according to Killip, functional classes of heart failure, cardiac arrhythmias, type of malignant neoplasm, and hospital mortality were assessed.
Results. In patients with current oncological process, MI with ST segment elevation was more commonly occured, in those with previous malignant neoplasm more commonly occured MI without ST segment elevation. In the latter, AHF was often not detected, while AHF of Killip classes 2–4 developed with greater frequency in patients of group II. The percentage of patients with chronic kidney disease stages 3b–4 was higher (38.7%) in the sample of patients with active malignant neoplasms, while among patients with previous malignant neoplasms it was 20.9%, and in those with MI without malignant neoplasm – 15%.
Conclusion. Patients with active malignant neoplasms had such features of MI course as a higher prevalence of ST-segment elevation on the ECG and more severe acute heart failure; in addition, they most often had gastrointestinal malignant neoplasms. Patients with a history of cancer more often did not have acute heart failure and had a not often variant of MI with ST-segment elevation.
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##article.viewOnOriginalSite##About the authors
Elizaveta G. Skorodumova
I.I. Dzhanelidze Saint Petersburg Research Institute of Emergency Care
Author for correspondence.
Email: lisavetta91@mail.ru
ORCID iD: 0000-0002-4961-5570
MD, PhD (Medicine), senior researcher
Russian Federation, Saint PetersburgElena A. Skorodumova
I.I. Dzhanelidze Saint Petersburg Research Institute of Emergency Care
Email: elskor@mail.ru
ORCID iD: 0000-0002-5017-0214
MD, Dr. Sci. (Medicine), leading researcher
Russian Federation, Saint PetersburgViktor A. Kostenko
I.I. Dzhanelidze Saint Petersburg Research Institute of Emergency Care
Email: vic2012tor@gmail.com
ORCID iD: 0000-0002-7015-1010
MD, Dr. Sci. (Medicine)
Russian Federation, Saint PetersburgAnna V. Siverina
I.I. Dzhanelidze Saint Petersburg Research Institute of Emergency Care
Email: gudkovanna_09@mail.ru
ORCID iD: 0000-0002-6831-2153
MD, PhD (Medicine), researcher
Russian Federation, Saint PetersburgReferences
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