Interactions Between Viral and Bacterial Pathogens in Infection Development: A Review with an Emphasis on Herpes Simplex Virus (HSV)

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Abstract

The interaction between viruses and bacteria has a significant impact on human health, affecting various microbial ecosystems in the respiratory and urogenital tracts as well as in cases of ventilator-associated pneumonia. These interactions can be complex and contribute to the development of diseases. Some interactions benefit the virus directly, while others indirectly create conditions favorable for bacterial growth. For instance, viruses can damage epithelial cells, disrupt the immune system, and alter the composition of the microbiota, making the host more susceptible to bacterial infections. Conversely, bacterial species can influence viral infections by altering the host environment and potentially contributing to viral transmission. Herpes simplex virus (HSV) is a common infection caused by two types, HSV-1 and HSV-2, which can lead to various illnesses ranging from mild mucocutaneous infections to severe neurological and systemic complications. HSV-1 is often associated with cold sores, while HSV-2 primarily causes genital herpes. Both viruses are highly contagious and spread through close contact. While there’s no cure, antiviral medications can manage symptoms and reduce transmission. The prevalence of HSV-2 varies globally and is influenced by factors such as geographic location, gender, and sexual behavior. The virus can cause a wide range of symptoms depending on the infection site and the individual’s immune system. HSV can interact with various bacterial species to influence the development and progression of disease. For example, it can exacerbate periodontal disease by creating conditions favorable for bacterial growth or increase the risk of acquiring bacterial infections such as Staphylococcus aureus and Acinetobacter baumannii. Conversely, some bacteria, like Lactobacillus crispatus, can inhibit HSV infection. Additionally, HSV can interact with bacteria in specific disease contexts, such as increasing the severity of ventilator-associated pneumonia or facilitating bacterial urinary tract infections. Moreover, bacterial vaginosis is associated with an increased risk of HSV-2 acquisition. Overall, this review underscores the necessity for ongoing research into viral-bacterial interactions, particularly focusing on HSV, to enhance our understanding of disease pathogenesis and improve therapeutic and public health strategies.

About the authors

Mohammad Hassan Kalantar Neyestanaki

Arak University of Medical Sciences

Email: mohakani@yahoo.com

Medical Doctor, Department of Medicine

Iran, Islamic Republic of, Arak

Aida Mehdipour

Qom University of Medical Sciences

Author for correspondence.
Email: mkalantar1998@gmail.com

Associate Professor, Pediatric Dentistry Specialist, Cellular and Molecular Research Center

Iran, Islamic Republic of, Qom

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