Genetics of multiple sclerosis today
- Авторы: Sokolova E.A.1,2, Boyarskikh U.A.1, Aulchenko Y.S.2,3, Filipenko M.L.1,2
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Учреждения:
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
- Novosibirsk State University
- Institute of Cytology and Genetics, Siberian Branch
- Выпуск: Том 6, № 2 (2016)
- Страницы: 113-125
- Раздел: Article
- URL: https://bakhtiniada.ru/2079-0864/article/view/206209
- DOI: https://doi.org/10.1134/S2079086416020080
- ID: 206209
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Аннотация
Multiple sclerosis is a common multifactorial disease in which the etiology of the interaction between external factors and structural specificities of a large number of genes plays an important role. Identification of the risk factors for multiple sclerosis and the development of an integrated pathogenesis model is a challenging task for neurology. The goal of the current review is to describe current approaches to studying the genetics of multifactorial diseases on the whole and multiple sclerosis in particular. Basic approaches to the design of the genetic epidemiological studies are described. Towards this end we discuss the gene candidate and the whole-genome methods of studying genetic associations, the statistical approaches used to combine the diverse data, namely, meta-analysis of the results of different studies, analysis of the association with groups of functionally related genes, and comparison of the genetic bases of the diseases with similar pathogenesis.
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Об авторах
E. Sokolova
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch; Novosibirsk State University
Автор, ответственный за переписку.
Email: max@niboch.nsc.ru
Россия, pr. Akademika Lavrent’eva 8, Novosibirsk, 630090; ul. Pirogova 2, Novosibirsk, 630090
U. Boyarskikh
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
Email: max@niboch.nsc.ru
Россия, pr. Akademika Lavrent’eva 8, Novosibirsk, 630090
Yu. Aulchenko
Novosibirsk State University; Institute of Cytology and Genetics, Siberian Branch
Email: max@niboch.nsc.ru
Россия, ul. Pirogova 2, Novosibirsk, 630090; pr. Akademika Lavrent’eva 10, Novosibirsk, 630090
M. Filipenko
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch; Novosibirsk State University
Email: max@niboch.nsc.ru
Россия, pr. Akademika Lavrent’eva 8, Novosibirsk, 630090; ul. Pirogova 2, Novosibirsk, 630090
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