Intestinal fatty acid binding protein as biomarker of enterocyte injury in patients with renal failure
- Authors: Pyatchenkov M.O.1, Sherbakov E.V.1, Trandina A.E.1, Belskykh A.N.1
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Affiliations:
- Military Medical Academy
- Issue: Vol 15, No 3 (2023)
- Pages: 37-41
- Section: Original Articles
- URL: https://bakhtiniada.ru/2075-3594/article/view/275320
- DOI: https://doi.org/10.18565/nephrology.2023.3.30-36
- ID: 275320
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Abstract
Aim: to evaluate serum intestinal fraction of the fatty acid binding protein (I-FABP) in subjects at different stages of chronic kidney disease (CKD), including those receiving hemodialysis treatment.
Material and methods. The cross-sectional study included 3 groups of patients: 1) 20 relatively healthy individuals with GFR>60 ml/min/1.73 m2; 2) 30 patients with CKD C3a-5 (GFR<60 ml/min/1.73 m2); 3) 38 patients with end-stage renal disease (ESRD) receiving hemodialysis treatment. All participants had no clinical manifestations of intestinal pathology. The concentration of I-FABP in blood serum was assessed by ELISA using commercially available kit.
Results. I-FABP levels significantly increased in parallel with an advance of renal insufficiency and reached maximum values in patients with ESRD: 1719,5 (1279,8–1979,6), 3533,2 (2449,5–4234,1), 6340,7 (5436–6732,3) pg/ml respectively. In subjects at the predialysis stages of CKD, a strong inverse correlation of I-FABP with GFR was found (R=0,946, p<0.001).
Conclusion. A decrease in GFR leads to a significant increase of serum I-FABP levels in patients with impaired renal function. This should be taken into account when using I-FABP as a biomarker of enterocytes injury in patients with renal failure.
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##article.viewOnOriginalSite##About the authors
Mikhail O. Pyatchenkov
Military Medical Academy
Email: pyatchenkovMD@yandex.ru
ORCID iD: 0000-0002-5893-3191
SPIN-code: 5572-8891
candidate of medical Sciences, senior lecturer of Department of nephrology and blood purification
Russian Federation, 6, str. Akademika Lebedeva, 194044 Saint PetersburgEvgeniy V. Sherbakov
Military Medical Academy
Email: evgenvmeda@mail.ru
ORCID iD: 0000-0002-3045-1721
SPIN-code: 6337-6039
nephrologist in the Military Medical Academy
Russian Federation, 6, str. Akademika Lebedeva, 194044 Saint PetersburgAleksandra E. Trandina
Military Medical Academy
Email: sasha-trandina@rambler.ru
ORCID iD: 0000-0003-1875-1059
SPIN-code: 6089-3495
doctor of clinical laboratory diagnostics Research department (Biomedical Research) of the RC
Russian Federation, 6, str. Akademika Lebedeva, 194044 Saint PetersburgAndrei N. Belskykh
Military Medical Academy
Author for correspondence.
Email: d0c62@mail.ru
ORCID iD: 0000-0002-0421-3797
Scopus Author ID: 273050
doctor of medical Sciences, Professor, Corresponding Member, Russian Academy of Sciences, Head of Department of nephrology and blood purification
Russian Federation, 6, str. Akademika Lebedeva, 194044 Saint PetersburgReferences
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