The nature of the reparative process of tissues in the cesarean section area in pregnant women with a comorbid
- Authors: Markina A.E.1, Vlasov A.P.1, Leschankina N.Y.1, Kapitanova D.A.1, Kormishkin A.E.1, Vlasova T.I.1
-
Affiliations:
- Ogarev Mordovia State University
- Issue: No 2 (2025)
- Pages: 154-165
- Section: PHYSIOPATHOLOGY
- URL: https://bakhtiniada.ru/2072-3032/article/view/306776
- DOI: https://doi.org/10.21685/2072-3032-2025-2-14
- ID: 306776
Cite item
Full Text
Abstract
Background. At this moment, the number of cesarean section deliveries has in creased, which raises the risk of postoperative complications, especially in patients with a comorbid background. The aim of the work was to establish the features of the reparative process of the tissues of the cesarean section area with a different comorbid background (preeclampsia, obesity). Material and methods. The analysis was performed on 102 preg nant women, that underwent cesarean section. Group 1 (25) – pregnant women without comorbid pathology, group 2 (27) – women with 2nd degree of obesity; group 3 (22) – with 3rd degree of obesity; group 4 (28) – with moderate and severe preeclampsia. The healing process of laparotomy wound tissues was evaluated. The obtained digital data was pro cessed by the method of variation statistics. Results. In pregnant women with preeclampsia and obesity, especially with grade 3, the healing of abdominal wall tissues in the cesarean section area in the early postoperative period proceeds at a slow tempo. According to the assessment of the cytological material, the prolongation of the inflammatory phase and its delayed transition to the reparative phase have been established. This has been confirmed by clinical tests. In vitro studies have established the effect of plasma from pregnant women with preeclampsia on the metabolic activity and regenerative potential of dermal fibroblast cultures. Conclusion. In women in labor with moderate and severe preeclampsia, as well as with third-degree obesity who underwent cesarean delivery, the reparative regeneration of laparotomy wound tissues gone slowly and is manifested in the early stages by a significant decrease in the degenerative-degenerative index, slowing down the transformation of poly blasts into tissue forms. In vitro studies have established the effect of plasma from pregnant women with preeclampsia on the metabolic activity and regenerative potential of dermal fi broblast cultures; no significant differences were found in comorbid obesity.
Keywords
About the authors
Alina E. Markina
Ogarev Mordovia State University
Author for correspondence.
Email: vap.61@yandex.ru
Applicant of the sub-department of faculty surgery with courses in topographic anatomy and operative surgery, urology and pediatric surgery, Medical Institute
(68 Bolshevistskaya street, Saransk, Russia)Aleksey P. Vlasov
Ogarev Mordovia State University
Email: vap.61@yandex.ru
Doctor of medical sciences, professor, head of the sub-department of faculty surgery with courses in topographic anatomy and operative surgery, urology and pediatric surgery, Medical Institute
(68 Bolshevistskaya street, Saransk, Russia)Nina Yu. Leschankina
Ogarev Mordovia State University
Email: bream25@yandex.ru
Doctor of medical sciences, associate professor, professor of the sub-department of hospital therapy, Medical Institute
(68 Bolshevistskaya street, Saransk, Russia)Darya A. Kapitanova
Ogarev Mordovia State University
Email: darjakap@yandex.ru
Student, Medical Institute
(68 Bolshevistskaya street, Saransk, Russia)Aleksandr E. Kormishkin
Ogarev Mordovia State University
Email: shishckt@yandex.ru
Candidate of medical sciences, associate professor of the sub-department of faculty surgery with courses in topographic anatomy and operative surgery, urology and pediatric surgery, Medical Institute
(68 Bolshevistskaya street, Saransk, Russia)Tatyana I. Vlasova
Ogarev Mordovia State University
Email: v.t.i@bk.ru
Doctor of medical sciences, professor, head of the sub-department of normal and pathological physiology, Medical Institute
(68 Bolshevistskaya street, Saransk, Russia)References
- Pelogeina E.I. Retrospective analysis of indications for first cesarean section and intergenetic interval as risk factors for developing persistent uterine scarring. 8-ya itogovaya nauchnaya sessiya molodykh uchenykh ROSTGMU = The 8th final scientific session of young scientists of Rostoc State Medical University. Rostov n/D, 2021:22‒23. (In Russ.)
- Sukhikh G.T., Savel'eva G.M., Radzinskiy V.E. (eds.). Akusherstvo i ginekologiya. Novosti. Mneniya. Obuchenie = Obstetrics and gynecology. News. Opinions. Education. 2017;(2):82. (In Russ.)
- Vuchenovich Yu.D., Olenev A.S., Novikova V.A., Radzinskiy V.E. Caesarean section: the boundaries of risks and safety. Akusherstvo i ginekologiya. Novosti. Mneniya. Obuchenie = Obstetrics and gynecology. News. Opinions. Education. 2019;7(3):93‒101. (In Russ.)
- Filippov O.S., Guseva E.V., Pavlov K.D. Global and domestic trends in the dynamics of maternal mortality. Problemy reproduktsii = Reproductive problems. 2024;30(1):100‒108. (In Russ.)
- Markaryan N.M., Golikova T.P., Esipova L.N. Caesarean Section. Unresolved Issues. Vestnik RUDN = Bulletin of RUDN. 2016;(2):143‒150. (In Russ.)
- Budanov P.V., Regul S.V. Modern structure and prevalence of complications of abdominal delivery. Zdorov'e i obrazovanie v XXI veke = Health and education in the 21st century. 2018;20(3):32‒35. (In Russ.)
- Radzinskiy V.E., Solov'eva A.V., Kuleshov V.M., Katkova N.Yu., Mingaleva N.V., Korotkikh I.N., Oboskalova T.A., Vorontsova A.V. Possibility of improving the health of overweight and obese women at the pre-pregnancy preparation stage. Akusherstvo i ginekologiya = Obstetrics and gynecology. 2023;(1):83‒90. (In Russ.)
- Akhmadeev N.R., Radzinskiy V.E., Fatkullin I.F. Severe preeclampsia and its impact on the risk of maternal mortality. Akusherstvo i ginekologiya. Novosti. Mneniya. Obuchenie = Obstetrics and gynecology. News. Opinions. Education. 2024;12(3):6‒12. (In Russ.)
- Dudnikova A.V., Konchakova E.A., Bedikyan E.A., Ershova E.R., Agutenkov R.V. Modern concepts of the mechanisms of preeclampsia development. Vrach = Doctor. 2024;35(1):40‒43. (In Russ.)
- Davydova E.A., Vlasov A.P., Markina A.E., Vlasova T.I., Sardaeva D.G. Peculiarities of tissue healing of laparotomy wound after cesarean section in obesity. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki = University proceedings. Volga region. Medical sciences. 2024;(3):175‒186. (In Russ.)
- Chiarello D.I., Abad C., Rojas D., Toledo F., Vázquez C.M., Mate A., Sobrevia L., Marín R. Oxidative stress: Normal pregnancy versus preeclampsia. Biochim. Biophys. Acta Mol. Basis Dis. 2020;1866(2). ID 165354. doi: 10.1016/j.bbadis.2018.12.005
- Teselkin Yu.O., Babenkova I.V., Lebedeva S.Yu., Vykhristyuk Yu.V., Shalina R.I., Titov V.Yu., Kurtser M.A., Vladimirov Yu.A., Osipov A.N. Ischemia-modified albumin and serum antioxidant capacity in normal pregnancy and preeclampsia. Byulleten' eksperimental'noy biologii i meditsiny = Bulletin of experimental biology and medicine. 2024;178(7):59‒64. (In Russ.)
- Davydov Yu.A., Larichev A.B., Kozlov A.G. Pathogenetic mechanisms of the influence of vacuum therapy on the course of the wound process. Khirurgiya = Surgery. 1990;(6):42‒47. (In Russ.)
Supplementary files
