Studying the influence of plant complexes on biochemical parameters and morphological picture of organs and tissues in experimental atherosclerosis
- Авторлар: Zamotaeva M.N.1, Chairkin I.N.2, Chairkina N.V.3, Siprov A.V.1, Maltseva Y.V.1
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Мекемелер:
- Ogarev Mordovia State University
- Institute of Anatomy and Morphology named after Academician Yu.M. Lopukhin, Russian National Research Medical University named after N.I. Pirogov
- Institute of Human Biology and Pathology, Russian National Research Medical University named after N.I. Pirogov
- Шығарылым: № 2 (2025)
- Беттер: 145-153
- Бөлім: PHYSIOPATHOLOGY
- URL: https://bakhtiniada.ru/2072-3032/article/view/306773
- DOI: https://doi.org/10.21685/2072-3032-2025-2-13
- ID: 306773
Дәйексөз келтіру
Толық мәтін
Аннотация
Background. Study of changes in biochemical and morphological parameters in rats with experimental atherosclerosis and the influence of plant complexes on them. Mate rials and methods. On a cholesterol model of atherosclerosis in rats, the hypolipidemic, hy poglycemic, cardioprotective, and hepatoprotective effects of plant complexes were stud ied: 1st – based on garlic and beetroot, 2nd – based on dioscorea, hawthorn, red clover, and beetroot, 3rd – based on thyme, blueberry, horsetail, and rose hips. Results. It was found that the most effective herbal complex for hyperlipidemia with elevated levels of low-density lipoproteins was based on blueberries, and for hypertriglyceridemia - based on garlic. All the studied herbal complexes have a hepatoprotective and cardioprotective effect, improv ing the biochemical parameters and morphological picture of liver and heart tissue in ather osclerosis, and also normalize uric acid metabolism. The herbal complex based on garlic has a pronounced sugar-lowering effect. Possible mechanisms of action of the studied herb al complexes are discussed. Conclusions. The obtained results indicate the presence of high hypolipidemic activity and pleiotropic effects in plant complexes based on garlic, blueber ries and dioscorea.
Негізгі сөздер
Авторлар туралы
Maria Zamotaeva
Ogarev Mordovia State University
Хат алмасуға жауапты Автор.
Email: zamy03@mail.ru
Candidate of medical sciences, associate professor, associate professor of the sub-department of pharmacology and clinical pharmacology with a course in pharmaceutical technology, Medical Institute
(68 Bolshevistskaya street, Saransk, Russia)Ivan Chairkin
Institute of Anatomy and Morphology named after Academician Yu.M. Lopukhin, Russian National Research Medical University named after N.I. Pirogov
Email: chairkin@rambler.ru
Doctor of medical sciences, professor, professor of the sub-department of human anatomy
(1 Ostrovityanova street, Moscow, Russia)Natalya Chairkina
Institute of Human Biology and Pathology, Russian National Research Medical University named after N.I. Pirogov
Email: chairkin@rambler.ru
Doctor of medical sciences, professor, associated professor of the sub-department of pathological anatomy and clinical pathological anatomy
(1 Ostrovityanova street, Moscow, Russia)Aleksandr Siprov
Ogarev Mordovia State University
Email: alek-s13@mail.ru
Doctor of medical sciences, professor, head of the sub department of pharmacology and clinical pharmacology with a course in pharmaceutical technology, Medical Institute
Yulia Maltseva
Ogarev Mordovia State University
Email: julyy-y@mail.ru
Resident of the sub-department of hospital therapy, Medical Institute
(68 Bolshevistskaya street, Saransk, Russia)Әдебиет тізімі
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