Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid

E. V. Salimova; A. G. Mamaev; E. V. Tret’yakova; O. S. Kukovinets; A. R. Mavzyutov; K. Yu. Shvets; L. V. Parfenova

doi:10.1134/S1070428018090245

Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid

作者: Salimova E.V.¹, Mamaev A.G.¹, Tret’yakova E.V.¹, Kukovinets O.S.², Mavzyutov A.R.³, Shvets K.Y.²^,3, Parfenova L.V.¹
隶属关系:
1. Institute of Petrochemistry and Catalysis
2. Bashkir State University
3. Bashkir State Medical University
期: 卷 54, 编号 9 (2018)
页面: 1411-1418
栏目: Article
URL: https://bakhtiniada.ru/1070-4280/article/view/219069
DOI: https://doi.org/10.1134/S1070428018090245
ID: 219069

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详细

3,11-Dihydroxy and 3,11-dioxo triterpenoids of the fusidane series reacted with acrylonitrile in 1,4-dioxane in the presence of alkali and phase-transfer catalyst to give mono- and bis(2-cyanoethoxy) and 2-cyanoethyl derivatives. The reaction with 3,11-dioxo analog afforded 2,2-disubstituted derivative as a result of addition of two cyanoethyl groups to the α-position with respect to the C³=O carbonyl group. The isolated compounds were screened for antibacterial and antifungal activities.