Reaction of 2-(2-Oxo-1,2-dihydro-3 H -pyrrol-3-ylidene)- malononitriles with C-Nucleophiles. Synthesis of New Spiro-Fused Pyrrole Derivatives

A. G. Milovidova; M. Yu. Belikov; M. Yu. Ievlev; O. V. Ershov; O. E. Nasakin

doi:10.1134/S1070428018120084

Reaction of 2-(2-Oxo-1,2-dihydro-3H-pyrrol-3-ylidene)- malononitriles with C-Nucleophiles. Synthesis of New Spiro-Fused Pyrrole Derivatives

Authors: Milovidova A.G.¹, Belikov M.Y.¹, Ievlev M.Y.¹, Ershov O.V.¹, Nasakin O.E.¹
Affiliations:
1. I.N. Ul’yanov Chuvash State University
Issue: Vol 54, No 12 (2018)
Pages: 1790-1793
Section: Article
URL: https://bakhtiniada.ru/1070-4280/article/view/219506
DOI: https://doi.org/10.1134/S1070428018120084
ID: 219506

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Abstract

Base-catalyzed nucleophilic addition of carbon nucleophiles to the exocyclic double bond of 2-(5-aryl-4-methyl-2-oxo-1,2-dihydro-3H-pyrrol-3-ylidene)malononitriles afforded spiro-fused pyrrole derivatives, 7-amino-3-aryl-4-methyl-1-oxo-8-oxa-2-azaspiro[4.5]deca-3,6,9-triene-6-carbonitriles. The products can be regarded as rare structural analogs of biologically active spirans based on isatin.