Cell-Viability Analysis Against MCF-7 Human Breast Cell Line and Antimicrobial Evaluation of Newly Synthesized Selenoxopyrimidines

Resumo

New selenoxopyrimidines were synthesized by one-pot multicomponent reaction of ethyl aceto-acetate, with aromatic aldehydes and selenourea in acidic medium. The synthesized compounds were shown to possess a broad spectrum of antimicrobial activity in vitro. The in vitro anticancer activity of some compounds was studied against MCF-7 human breast cell line using MTT assay. All tested compounds have shown a significant anticancer activity, and 4-phenyl-substituted derivative was found to be most effective anticancer agent (cell viability 50% against 41% for Paclitaxel). The structure-activity relationship (SAR) analysis showed that electron-donating substituents favor anticancer and antibacterial activity and that electron-withdrawing substituents favor antifungal activity.