Synthesis of 1-(oxiran-2-ylmethyl)-1H-indole-3-carbaldehyde and its transformation into amino alcohols containing an indan-1,3-dione fragment

Resumo

A procedure for the synthesis of 1-(oxiran-2-ylmethyl)-1H-indole-3-carbaldehyde was developed and optimized. Its reaction with indan-1,3-dione, followed by treatment with amines, afforded 1,2-amino alcohols containing an indole fragment.