Email this article One-Step Three-Component Synthesis of New 2,5,6,7-Functionalized 5,8-Dihydropyrido-[2,3-d]pyrimidin-4(3H)-ones
- Authors: Melik-Ohanjanyan R.G.1, Hovsepyan T.R.1, Karakhanyan G.S.1, Israelyan S.G.1, Nersesyan L.E.1, Panosyan G.A.2
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Affiliations:
- Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
- Molecular Structure Research Center, Scientific Technological Center of Organic and Pharmaceutical Chemistry
- Issue: Vol 54, No 1 (2018)
- Pages: 107-111
- Section: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/217165
- DOI: https://doi.org/10.1134/S1070428018010104
- ID: 217165
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Abstract
One-step three-component cyclocondensation of 2,6-disubstituted pyrimidin-4(3H)-ones with 1,3-dicarbonyl compounds and some aromatic and heterocyclic aldehydes on heating or under microwave irradiation afforded new functionally substituted 5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-ones. Conventional heating was found to be more advantageous. The effects of the 2-substituent in the initial pyrimidin-4(3H)-one and the nature of the dicarbonyl component on the product structure and yield were analyzed.
About the authors
R. G. Melik-Ohanjanyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
T. R. Hovsepyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
Author for correspondence.
Email: tag.hovsepyan@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
G. S. Karakhanyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
S. G. Israelyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
L. E. Nersesyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
G. A. Panosyan
Molecular Structure Research Center, Scientific Technological Center of Organic and Pharmaceutical Chemistry
Email: tag.hovsepyan@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
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