


Vol 53, No 3 (2017)
- Year: 2017
- Articles: 33
- URL: https://bakhtiniada.ru/1070-4280/issue/view/13437
Article
Catalytic thiomethylation of N-substituted ureas and thioureas with N,N,N′,N′-tetramethylmethanediamine and α,ω-alkanedithiols
Abstract
An efficient procedure has been developed for the synthesis of N,N′-(2,5-dithiaalkane-α,ω-diyl)bis-(N′-allylthioureas) by thiomethylation of N-substituted ureas and thioureas with α,ω-alkanedithiols and N,N,N′,N′-tetramethylmethanediamine in the presence of cesium carbonate as catalyst.



Reactions of selenium dihalides with vinylbenzenes
Abstract
Alkoxyselenation of vinylbenzenes with selenium dihalides was accomplished for the first time. The reaction with selenium dibromide was the most efficient. Selenium dibromide reacted with vinylbenzene and 1-chloro-4-(prop-1-en-2-yl)benzene in chloroform or methylene chloride in the presence of methanol or ethanol to give the corresponding Markovnikov adducts, bis(2-alkoxy-2-phenylethyl) selenides and bis[2-alkoxy-2-(4-chlorophenyl)propyl] selenides in 82–95% yield with high regioselectivity. Bis(2-halo-2-phenylethyl) selenides can be obtained at low temperature (–60°C).



Reactions of γ-sultones containing a polycyclic fragment
Abstract
Hydrolytic cleavage of cage γ-sultones have been studied. Alkaline hydrolysis of homoadamantane γ-sultone leads to the formation of sulfonates with erythro configuration. The reduction of homoadamantane γ-sultone with LiAlH4–AlCl3 yields desulfurization and deoxygenation products.



Synthesis of new enantiomerically pure β-amino alcohols of the pinane series
Abstract
A series of new β-amino alcohols with pinane structure, (+)- and (‒)-3α-amino-10β-pinan-4β-ols, 4β-amino-10β-pinan-3α-ol, and 4α-amino-10β-pinan-3α-ol have been synthesized with the goal of using them as organocatalysts in the aldol reaction of isatin with acetone.



Synthesis of lactide from lactic acid and its esters in the presence of rare-earth compounds
Abstract
A procedure is described for the synthesis of lactide by dehydration of L-lactic acid and subsequent depolymerization of its oligomer mixture in the presence of yttrium(III) and praseodymium(III) oxides, as well as of cerium(III) chloride heptahydrate. The catalytic activity of yttrium and praseodymium sesquioxides was determined at different temperatures at the oligomerization and deoligomerization stages. Ethyl lactate was prepared in the presence of Purolite C100 MB cation exchange resin and subjected to oligomerization followed by thermal decomposition of oligoester and oligolactic acid mixture in the presence of yttrium(III) and praseodymium(III) oxides and aqueous cerium(III) chloride.



Reactivity of inorganic α-nucleophiles in acyl group transfer processes in water and surfactant micelles: I. Systems based on organic complexes of tribromide anion
Abstract
Systems based on organic complexes of tribromide anion generate upon dissolution in water nucleophile–oxidant couple HOBr/BrO– and accelerate hydrolysis of ethyl 4-nitrophenyl ethylphosphonate, diethyl 4-nitrophenyl phosphate, and 4-nitrophenyl p-toluenesulfonate by a factor of 15–90 in the presence of cationic surfactant micelles. As in water, hypobromite ion in surfactant micelles acts as α-nucleophile, and the magnitude of the α-effect almost does not change in going from water to micelles. Micellar effects of surfactants are determined by the nucleophilicity of hypobromite ion in surfactant micelles and by solubilization of the substrate and BrO–, which largely depend on the counterion concentration in the micelle surface layer. The main factor responsible for the observed acceleration is increased reactant concentration in the micellar pseudophase.






Synthesis and biological activity of 1-(aryloxy)-3-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)propan-2-ols
Abstract
Treatment of 1-(4-chlorobenzylamino)-2-methylpropan-2-ol with concentrated sulfuric acid at 0°C gave 6-chloro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline which reacted with (aryloxymethyl)oxiranes to afford new propan-2-ol derivatives of the tetrahydroisoquinoline series, 1-(aryloxy)-3-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)propan-2-ols. Some of the synthesized compounds or their hydrochlorides showed moderate adrenergic blocking and sympatholytic activities.



Photochromic fluorescent indol-3-yl-substituted maleimides
Abstract
New hetarylethenes, 3-(indol-3-yl)-4-thienyl(but-1-en-1-yl)-substituted pyrrole-2,5-diones containing coumarin or fluorene substituents on the pyrrole nitrogen atom, were synthesized by reactions of furan-2,5-diones with 9H-fluoren-2-amine and 6-amino-2H-chromen-2-one. Acyclic maleimide isomers showed fluorescence with quantum yields of 0.002 to 0.072. Their irradiation with UV light generates non-fluorescing cyclic isomer. The reverse ring opening occurs in the excited state.






Differentiation of keto groups in the Michael adducts of levoglucosenone with cyclohexanone
Abstract
The keto group in the carbohydrate residue of diastereoisomeric Michael adducts of levoglucosenone and cyclohexanone is more reactive than that in the cyclohexanone fragment. The adducts have been converted to the corresponding ethylene, trimethylene, and dimethyl ketals, tosylhydrazones, oxiranes, and Wittig methylenation products with complete or high regioselectivity.



N → N acyl group migration in N-acylpyrazoles: Isomerization of 1,4-diacyl-5-methyl-1H-pyrazoles to 1,4-diacyl-3-methyl-1H-pyrazoles
Abstract
1,4-Diacyl-5-methyl-1H-pyrazoles on heating in toluene undergo isomerization to 1,4-diacyl-3-methyl-1H-pyrazoles via intermolecular N → N acyl group migration. 1,4,5-Trisubstituted pyrazoles obtained by reaction of 2-ethoxymethylidene derivatives of 1,3-diketones with 1,3-benzothiazol-2-ylhydrazine or phenylhydrazine failed to isomerize to 1,3,4-trisubstituted pyrazoles.



Cycloadducts of phenylethynyl trifluoromethyl sulfone with diphenyldiazomethane and 9-diazofluorene and their transformations under conditions of van Alphen–Hüttel rearrangement
Abstract
Diphenyldiazomethane and 9-diazofluorene react with phenylethynyl trifluoromethyl sulfone in diethyl ether at 20°C to give 1,3-dipolar cycloaddition products according to the von Auwers rule, the corresponding 3H-pyrazoles. The adduct with diphenyldiazomethane undergoes thermal van Alphen–Hüttel rearrangement to 4,4,5-triphenyl-3-(trifluoromethanesulfonyl)-4H-pyrazole on heating in boiling benzene. Under analogous conditions, the adduct with 9-diazofluorene is converted into 3′-phenylspiro[fluorene-9,4′-pyrazol]-5′(1′H)-one, whereas 3a-phenyl-2,3a-dihydro-3H-dibenzo[e,g]indazol-3-one is formed in boiling methanol. The structure of 3′-phenylspiro[fluorene-9,4′-pyrazol]-5′(1′H)-one was determined by X-ray analysis.



Synthesis of 1-[4-(1,3-diaryl-4,5-dihydro-1H-pyrazol-5-yl)-2,3,5,6-tetrafluorophenyl]piperidin-4-ols and their acrylates
Abstract
(4-Hydroxypiperidin-1-yl)tetra- and -octafluorochalcones reacted with phenylhydrazine in acetic acid to give mixtures of polyfluoro-1,3,5-triaryl-4,5-dihydro-1H-pyrazoles and their O-acetyl derivatives. Analogous reactions in ethanol afforded in satisfactory yields 1-[4-(1,3-diaryl-4,5-dihydro-1H-pyrazol-5-yl)-2,3,5,6-tetrafluorophenyl]piperidin-4-ols which were treated with acryloyl chloride to obtain the corresponding acrylates that are promising as monomers for the preparation of fluorescent films.



Polyfunctional imidazoles: XIII.1 Addition and cyclization reactions of 1-aryl-4-chloro-5-(2-nitroethenyl)-1H-imidazoles with sulfur and nitrogen nucleophiles
Abstract
1-Aryl-4-chloro-5-(2-nitroethenyl)-1H-imidazoles reacted with thiols and aromatic amines via Michael addition to give 5-[(1-arylsulfanyl)-2-nitroethyl)]-4-chloro-1H-imidazoles and N-[1-(1-aryl-4-chloro-1H-imidazol-5-yl)-2-nitroethyl]anilines, respectively. [2 + 3]-Cycloaddition of the title compounds to sodium azide afforded 4-(4-chloro-1H-imidazol-5-yl)-1H-1,2,3-triazoles.



Alkylation of 2-methylimidazole with iodomethylsilanes
Abstract
2-Methyl-1,3-bis[(1-methylsilolan-1-yl)methyl]-1H-imidazolium triiodide, 1,3-bis{[dimethyl-(phenyl)silyl]methyl}-2-methyl-1H-imidazolium iodide and triiodide, and cyclic 3,3,5,5,10-pentamethyl-4-oxa-7-aza-1-azonia-3,5-disilabicyclo[5.2.1]deca-1(10),8-diene iodide were synthesized by solvent-free reactions of 2-methyl-1H-imidazole with 1-(iodomethyl)-1-methylsilolane, (iodomethyl)(dimethyl)phenylsilane, and ethynyl(iodomethyl)(dimethyl)silanes, respectively, in the absence of base catalyst.



Synthesis and antimicrobial activity of tryptanthrin adducts with ketones
Abstract
Reactions of tryptanthrin with acetone, cyclopentanone, hexan-2-one, 4-methylpentan-2-one, 4-hydroxy-4-methylpentan-2-one, cyclohexanone, and butan-2-one in the presence of potassium carbonate afforded racemic phaitanthrin A and other addition products to the ketone group of tryptanthrin with high yields. Thermal dissociation, some chemical transformations, and antimicrobial activity of some adducts were studied, and inhibitory effect against gram-positive bacteria was found for particular derivatives.



Study of the mechanism of formation of heterocyclic disulfonium dications from 1,3-benzothiazole-2-thiol and 1-iodopropan-2-one
Abstract
The potential energy surface for the formation of heterocyclic disulfonium dications from 1,3-benzothiazole-2-thiol and 1-iodopropan-2-one has been analyzed at the DFT B3LYP level of theory. The reaction involves oxidation of 1,3-benzothiazole-2-thiol to the corresponding disulfide, followed by alkylation of the exocyclic sulfur atoms. Stabilization of the salt with iodide anion is initiated by thermodynamically controlled reaction with molecular iodine, leading to the formation of stable structure with triiodide anion.



Synthesis of new 4-amino-5-(1,4-benzodioxan-2-yl)-4H-1,2,4-triazole-3-thiol derivatives
Abstract
Acylation and cyclization reactions of 4-amino-5-(1,4-benzodioxan-2-yl)-4H-1,2,4-triazole-3-thiol were studied. Acylation of the title compound with substituted benzoyl chlorides gave the corresponding amides, whereas its reactions with substituted benzoic acids in the presence of POCl3 were accompanied by cyclization with formation of triazolothiadiazoles containing a 1,4-benzodioxane substituent. 4-Amino-5-(1,4-benzodioxan-2-yl)-4H-1,2,4-triazole-3-thiol reacted with substituted benzaldehydes to afford the corresponding Schiff bases, and its alkylation with chloroacetic acid in ethanol in the presence of sodium acetate gave S-ethoxycarbonylmethyl derivative.



New 2-substituted functionalized allyl halides in the synthesis of fragments of amphidinolides B, D, G, H, and L
Abstract
Simple and efficient asymmetric syntheses of several new allyl bromides as C9–C14 fragments of cytotoxic macrolactones, amphidinolides B, D, G, H, and L, have been developed starting from accessible 1-[(2S)-4,4-dimethoxy-2-methylbutyl]cyclopropyl methanesulfonate prepared through cyclopropanol intermediates. Original synthetic approaches to the C7–C16, C7–C14, and C9–C16 amphidinolide fragments are also described.



Synthesis of 3′H-cyclopropa[1,9](C60-Ih)[5,6]fullerenes from 2′-aryl-1′,1′-dimethyl-2′,5′-dihydro-1′H-pyrrolo[3′,4′:1,9]-(C60-Ih)[5,6]fulleren-1-ium iodides
Abstract
New 1′,1′-dimethyl-2′,5′-dihydro-1′H-pyrrolo[3′,4′:1,9](C60-Ih)[5,6]fulleren-1-ium iodides containing different aryl groups in position 2 of the pyrrolidine ring have been synthesized. Their reactions with bis-(toluene)chromine afforded the corresponding 3′-aryl-3′H-cyclopropa[1,9](C60-Ih)[5,6]fullerenes.



1,1,1-Trifluoroethane encapsulated in fullerenes: Structural and conformational features
Abstract
DFT PBE/3ζ study of the structure and conformations of 1,1,1-trifluoroethane molecule encapsulated in fullerenes C60 and C80, as well as in their analogs with boron–nitrogen units, showed that the encapsulated molecule is characterized by shortened C–C bond, negative charge, and considerably increased barrier to rotation about the carbon–carbon bond. All mentioned effects diminish in the case of C60 doped with boron and nitrogen atoms.



Three-component synthesis of 3-(diarylmethyl)indoles using Fe(ClO4)3/SiO2 as catalyst
Abstract
Three-component reaction of indole, aromatic aldehyde, and N,N-dimethyl aniline in the presence of silica-supported Fe(ClO4)3 as catalyst afforded the corresponding 3-[aryl(4-dimethylaminophenyl)methyl]-indoles in excellent yields under mild conditions. The proposed protocol offers some remarkable advantages such as the use of a solid catalyst and simple workup procedure.



New synthesis of 4-methoxyisophthalic acid
Abstract
A new synthetic route to 4-methoxyisophthalic acid, the key intermediate in the synthesis of Picotamide, is reported. The new protocol starts from commercially available and cheap 4-methylphenol and includes four steps: esterification, Fries rearrangement, methylation, and oxidation; the overall yield is 49%. Unlike the traditional Blanc chloromethylation/oxidation scheme, the proposed procedure avoids using volatile and corrosive hydrochloric acid.



Short Communications



Reaction of phosphorylated 2,6-di-tert-butyl-4-methylenecyclohexa-2,5-dien-1-ones with 2,2′-[1,3-phenylenebis(oxy)]-di(ethan-1-amine)
Abstract
Dialkyl [(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]phosphonates reacted with 2,2′-[1,3-phenylenebis(oxy)]di(ethan-1-amine) dihydrochloride at a ratio of 2: 1 in dioxane in the presence of potassium carbonate to give previously unknown tetraalkyl {1,3-phenylenebis[oxyethane-2,1-diylazanediyl-(3,5-di-tert-butyl-4-hydroxyphenylmethylene)]}bisphosphonates in high yields.









Epimeric sulfoxides derived from 8-methyl-5-(methylsulfanylmethyl)-3-thiabicyclo[3.3.1]non-7-en-6-one
Abstract
Epimeric mono- and bis-sulfoxides synthesized by oxidation of 8-methyl-5-(methylsulfanylmethyl)-3-thiabicyclo[3.3.1]non-7-en-6-one were separated by silica gel column chromatography. Their threo and erythro isomers were distinguished by signals of diastereotopic protons of the exocyclic methylene group.



Convenient synthesis of 3-chloroimidazo[1,5-a]quinoxalines
Abstract
5-Aminomethyl-1-(2-haloaryl)-4-chloroimidazoles prepared from 1-(2-haloaryl)-5-formyl-4-chloroimidazoles via simple transformations undergo intramolecular cyclization to 3-chloroimidazo[1,5-a]quinoxalines on heating in DMF in the presence of potassium carbonate.









Convenient synthesis of 1-norbornyl-5-R-1H-1,2,3-triazole-4-carboxylic acids
Abstract
A convenient procedure was developed for the synthesis of 2-azidobicyclo[2.2.1]heptane whose click reaction with phenylacetylene afforded 1-(bicyclo[2.2.1]heptan-2-yl)-4-phenyl-1H-1,2,3-triazol, and its reactions with ethyl α-bromoacrylate and ethyl acetoacetate gave 1-(bicyclo[2.2.1]heptan-2-yl)-5-R-1H-1,2,3-triazole-4-carboxylic acids.


