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Vol 53, No 3 (2017)

Article

Catalytic thiomethylation of N-substituted ureas and thioureas with N,N,N′,N′-tetramethylmethanediamine and α,ω-alkanedithiols

Khairullina R.R., Geniyatova A.R., Meshcheryakova E.S., Tyumkina T.V., Khalilov L.M., Ibragimov A.G., Dzhemilev U.M.

Abstract

An efficient procedure has been developed for the synthesis of N,N′-(2,5-dithiaalkane-α,ω-diyl)bis-(N′-allylthioureas) by thiomethylation of N-substituted ureas and thioureas with α,ω-alkanedithiols and N,N,N′,N′-tetramethylmethanediamine in the presence of cesium carbonate as catalyst.

Russian Journal of Organic Chemistry. 2017;53(3):315-321
pages 315-321 views

Reactions of selenium dihalides with vinylbenzenes

Potapov V.A., Khabibulina A.G., Musalov M.V., Albanov A.I., Amosova S.V.

Abstract

Alkoxyselenation of vinylbenzenes with selenium dihalides was accomplished for the first time. The reaction with selenium dibromide was the most efficient. Selenium dibromide reacted with vinylbenzene and 1-chloro-4-(prop-1-en-2-yl)benzene in chloroform or methylene chloride in the presence of methanol or ethanol to give the corresponding Markovnikov adducts, bis(2-alkoxy-2-phenylethyl) selenides and bis[2-alkoxy-2-(4-chlorophenyl)propyl] selenides in 82–95% yield with high regioselectivity. Bis(2-halo-2-phenylethyl) selenides can be obtained at low temperature (–60°C).

Russian Journal of Organic Chemistry. 2017;53(3):322-325
pages 322-325 views

Reactions of γ-sultones containing a polycyclic fragment

Leonova M.V., Baimuratov M.R., Klimochkin Y.N.

Abstract

Hydrolytic cleavage of cage γ-sultones have been studied. Alkaline hydrolysis of homoadamantane γ-sultone leads to the formation of sulfonates with erythro configuration. The reduction of homoadamantane γ-sultone with LiAlH4–AlCl3 yields desulfurization and deoxygenation products.

Russian Journal of Organic Chemistry. 2017;53(3):326-334
pages 326-334 views

Synthesis of new enantiomerically pure β-amino alcohols of the pinane series

Frolova L.L., Sudarikov D.V., Alekseev I.N., Banina O.A., Slepukhin P.A., Kutchin A.V.

Abstract

A series of new β-amino alcohols with pinane structure, (+)- and (‒)-3α-amino-10β-pinan-4β-ols, 4β-amino-10β-pinan-3α-ol, and 4α-amino-10β-pinan-3α-ol have been synthesized with the goal of using them as organocatalysts in the aldol reaction of isatin with acetone.

Russian Journal of Organic Chemistry. 2017;53(3):335-343
pages 335-343 views

Synthesis of lactide from lactic acid and its esters in the presence of rare-earth compounds

Poryvaeva E.A., Egiazaryan T.A., Makarov V.M., Moskalev M.V., Razborov D.A., Fedyushkin I.L.

Abstract

A procedure is described for the synthesis of lactide by dehydration of L-lactic acid and subsequent depolymerization of its oligomer mixture in the presence of yttrium(III) and praseodymium(III) oxides, as well as of cerium(III) chloride heptahydrate. The catalytic activity of yttrium and praseodymium sesquioxides was determined at different temperatures at the oligomerization and deoligomerization stages. Ethyl lactate was prepared in the presence of Purolite C100 MB cation exchange resin and subjected to oligomerization followed by thermal decomposition of oligoester and oligolactic acid mixture in the presence of yttrium(III) and praseodymium(III) oxides and aqueous cerium(III) chloride.

Russian Journal of Organic Chemistry. 2017;53(3):344-350
pages 344-350 views

Reactivity of inorganic α-nucleophiles in acyl group transfer processes in water and surfactant micelles: I. Systems based on organic complexes of tribromide anion

Turovskaya M.K., Mikhailov V.A., Burakov N.I., Kapitanov I.V., Zubareva T.M., Lobachev V.L., Panchenko B.V., Prokop’eva T.M.

Abstract

Systems based on organic complexes of tribromide anion generate upon dissolution in water nucleophile–oxidant couple HOBr/BrO and accelerate hydrolysis of ethyl 4-nitrophenyl ethylphosphonate, diethyl 4-nitrophenyl phosphate, and 4-nitrophenyl p-toluenesulfonate by a factor of 15–90 in the presence of cationic surfactant micelles. As in water, hypobromite ion in surfactant micelles acts as α-nucleophile, and the magnitude of the α-effect almost does not change in going from water to micelles. Micellar effects of surfactants are determined by the nucleophilicity of hypobromite ion in surfactant micelles and by solubilization of the substrate and BrO, which largely depend on the counterion concentration in the micelle surface layer. The main factor responsible for the observed acceleration is increased reactant concentration in the micellar pseudophase.

Russian Journal of Organic Chemistry. 2017;53(3):351-358
pages 351-358 views

Synthesis of alkyl biphenyl-4-carboxylates by reaction of biphenyl with carbon tetrachloride and alcohols in the presence of Fe2(CO)9

Bayguzina A.R., Erokhina I.S., Khusnutdinov R.I.

Abstract

Alkyl biphenyl-4-carboxylates have been synthesized with high selectivity by multicomponent reaction of biphenyl with carbon tetrachloride and aliphatic alcohols in the presence of iron-containing catalysts.

Russian Journal of Organic Chemistry. 2017;53(3):359-361
pages 359-361 views

Synthesis and biological activity of 1-(aryloxy)-3-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)propan-2-ols

Aghekyan A.A., Mkryan G.G., Tsatinyan A.S., Noravyan O.S., Gasparyan G.V.

Abstract

Treatment of 1-(4-chlorobenzylamino)-2-methylpropan-2-ol with concentrated sulfuric acid at 0°C gave 6-chloro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline which reacted with (aryloxymethyl)oxiranes to afford new propan-2-ol derivatives of the tetrahydroisoquinoline series, 1-(aryloxy)-3-(6-chloro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-2-yl)propan-2-ols. Some of the synthesized compounds or their hydrochlorides showed moderate adrenergic blocking and sympatholytic activities.

Russian Journal of Organic Chemistry. 2017;53(3):362-365
pages 362-365 views

Photochromic fluorescent indol-3-yl-substituted maleimides

Shepelenko E.N., Makarova N.I., Podshibyakin V.A., Tikhomirova K.S., Dubonosov A.D., Metelitsa A.V., Bren V.A., Minkin V.I.

Abstract

New hetarylethenes, 3-(indol-3-yl)-4-thienyl(but-1-en-1-yl)-substituted pyrrole-2,5-diones containing coumarin or fluorene substituents on the pyrrole nitrogen atom, were synthesized by reactions of furan-2,5-diones with 9H-fluoren-2-amine and 6-amino-2H-chromen-2-one. Acyclic maleimide isomers showed fluorescence with quantum yields of 0.002 to 0.072. Their irradiation with UV light generates non-fluorescing cyclic isomer. The reverse ring opening occurs in the excited state.

Russian Journal of Organic Chemistry. 2017;53(3):366-370
pages 366-370 views

New functionalized pyrrolidines

Egorov V.A., Khasanova L.S., Galeeva A.M., Gimalova F.A., Abdullin M.F., Miftakhov M.S.

Abstract

New functionalized pyrrolidines have been synthesized from accessible amino acids by the [C+NC+CC]-coupling reaction.

Russian Journal of Organic Chemistry. 2017;53(3):371-373
pages 371-373 views

Differentiation of keto groups in the Michael adducts of levoglucosenone with cyclohexanone

Galimova Y.S., Tagirov A.R., Faizullina L.K., Salikhov S.M., Valeev F.A.

Abstract

The keto group in the carbohydrate residue of diastereoisomeric Michael adducts of levoglucosenone and cyclohexanone is more reactive than that in the cyclohexanone fragment. The adducts have been converted to the corresponding ethylene, trimethylene, and dimethyl ketals, tosylhydrazones, oxiranes, and Wittig methylenation products with complete or high regioselectivity.

Russian Journal of Organic Chemistry. 2017;53(3):374-380
pages 374-380 views

N → N acyl group migration in N-acylpyrazoles: Isomerization of 1,4-diacyl-5-methyl-1H-pyrazoles to 1,4-diacyl-3-methyl-1H-pyrazoles

Petrov A.A., Pakal’nis V.V., Zerov A.V., Yakimovich S.I.

Abstract

1,4-Diacyl-5-methyl-1H-pyrazoles on heating in toluene undergo isomerization to 1,4-diacyl-3-methyl-1H-pyrazoles via intermolecular N → N acyl group migration. 1,4,5-Trisubstituted pyrazoles obtained by reaction of 2-ethoxymethylidene derivatives of 1,3-diketones with 1,3-benzothiazol-2-ylhydrazine or phenylhydrazine failed to isomerize to 1,3,4-trisubstituted pyrazoles.

Russian Journal of Organic Chemistry. 2017;53(3):381-392
pages 381-392 views

Cycloadducts of phenylethynyl trifluoromethyl sulfone with diphenyldiazomethane and 9-diazofluorene and their transformations under conditions of van Alphen–Hüttel rearrangement

Vasin V.A., Popkova Y.A., Bezrukova E.V., Razin V.V., Somov N.V.

Abstract

Diphenyldiazomethane and 9-diazofluorene react with phenylethynyl trifluoromethyl sulfone in diethyl ether at 20°C to give 1,3-dipolar cycloaddition products according to the von Auwers rule, the corresponding 3H-pyrazoles. The adduct with diphenyldiazomethane undergoes thermal van Alphen–Hüttel rearrangement to 4,4,5-triphenyl-3-(trifluoromethanesulfonyl)-4H-pyrazole on heating in boiling benzene. Under analogous conditions, the adduct with 9-diazofluorene is converted into 3′-phenylspiro[fluorene-9,4′-pyrazol]-5′(1′H)-one, whereas 3a-phenyl-2,3a-dihydro-3H-dibenzo[e,g]indazol-3-one is formed in boiling methanol. The structure of 3′-phenylspiro[fluorene-9,4′-pyrazol]-5′(1′H)-one was determined by X-ray analysis.

Russian Journal of Organic Chemistry. 2017;53(3):393-397
pages 393-397 views

Synthesis of 1-[4-(1,3-diaryl-4,5-dihydro-1H-pyrazol-5-yl)-2,3,5,6-tetrafluorophenyl]piperidin-4-ols and their acrylates

Soboleva E.A., Orlova N.A., Shelkovnikov V.V.

Abstract

(4-Hydroxypiperidin-1-yl)tetra- and -octafluorochalcones reacted with phenylhydrazine in acetic acid to give mixtures of polyfluoro-1,3,5-triaryl-4,5-dihydro-1H-pyrazoles and their O-acetyl derivatives. Analogous reactions in ethanol afforded in satisfactory yields 1-[4-(1,3-diaryl-4,5-dihydro-1H-pyrazol-5-yl)-2,3,5,6-tetrafluorophenyl]piperidin-4-ols which were treated with acryloyl chloride to obtain the corresponding acrylates that are promising as monomers for the preparation of fluorescent films.

Russian Journal of Organic Chemistry. 2017;53(3):398-406
pages 398-406 views

Polyfunctional imidazoles: XIII.1 Addition and cyclization reactions of 1-aryl-4-chloro-5-(2-nitroethenyl)-1H-imidazoles with sulfur and nitrogen nucleophiles

Chornous V.A., Mel’nik O.Y., Grozav A.N., Suikov S.Y., Vovk M.V.

Abstract

1-Aryl-4-chloro-5-(2-nitroethenyl)-1H-imidazoles reacted with thiols and aromatic amines via Michael addition to give 5-[(1-arylsulfanyl)-2-nitroethyl)]-4-chloro-1H-imidazoles and N-[1-(1-aryl-4-chloro-1H-imidazol-5-yl)-2-nitroethyl]anilines, respectively. [2 + 3]-Cycloaddition of the title compounds to sodium azide afforded 4-(4-chloro-1H-imidazol-5-yl)-1H-1,2,3-triazoles.

Russian Journal of Organic Chemistry. 2017;53(3):407-412
pages 407-412 views

Alkylation of 2-methylimidazole with iodomethylsilanes

Yarosh N.O., Zhilitskaya L.V., Shagun L.G., Dorofeev I.A., Larina L.I.

Abstract

2-Methyl-1,3-bis[(1-methylsilolan-1-yl)methyl]-1H-imidazolium triiodide, 1,3-bis{[dimethyl-(phenyl)silyl]methyl}-2-methyl-1H-imidazolium iodide and triiodide, and cyclic 3,3,5,5,10-pentamethyl-4-oxa-7-aza-1-azonia-3,5-disilabicyclo[5.2.1]deca-1(10),8-diene iodide were synthesized by solvent-free reactions of 2-methyl-1H-imidazole with 1-(iodomethyl)-1-methylsilolane, (iodomethyl)(dimethyl)phenylsilane, and ethynyl(iodomethyl)(dimethyl)silanes, respectively, in the absence of base catalyst.

Russian Journal of Organic Chemistry. 2017;53(3):413-417
pages 413-417 views

Synthesis and antimicrobial activity of tryptanthrin adducts with ketones

Deryabin P.I., Moskovkina T.V., Shevchenko L.S., Kalinovskii A.I.

Abstract

Reactions of tryptanthrin with acetone, cyclopentanone, hexan-2-one, 4-methylpentan-2-one, 4-hydroxy-4-methylpentan-2-one, cyclohexanone, and butan-2-one in the presence of potassium carbonate afforded racemic phaitanthrin A and other addition products to the ketone group of tryptanthrin with high yields. Thermal dissociation, some chemical transformations, and antimicrobial activity of some adducts were studied, and inhibitory effect against gram-positive bacteria was found for particular derivatives.

Russian Journal of Organic Chemistry. 2017;53(3):418-422
pages 418-422 views

Study of the mechanism of formation of heterocyclic disulfonium dications from 1,3-benzothiazole-2-thiol and 1-iodopropan-2-one

Shagun V.A., Dorofeev I.A., Shagun L.G.

Abstract

The potential energy surface for the formation of heterocyclic disulfonium dications from 1,3-benzothiazole-2-thiol and 1-iodopropan-2-one has been analyzed at the DFT B3LYP level of theory. The reaction involves oxidation of 1,3-benzothiazole-2-thiol to the corresponding disulfide, followed by alkylation of the exocyclic sulfur atoms. Stabilization of the salt with iodide anion is initiated by thermodynamically controlled reaction with molecular iodine, leading to the formation of stable structure with triiodide anion.

Russian Journal of Organic Chemistry. 2017;53(3):423-427
pages 423-427 views

Synthesis of new 4-amino-5-(1,4-benzodioxan-2-yl)-4H-1,2,4-triazole-3-thiol derivatives

Avakyan A.S., Vartanyan S.O., Sargsyan A.B.

Abstract

Acylation and cyclization reactions of 4-amino-5-(1,4-benzodioxan-2-yl)-4H-1,2,4-triazole-3-thiol were studied. Acylation of the title compound with substituted benzoyl chlorides gave the corresponding amides, whereas its reactions with substituted benzoic acids in the presence of POCl3 were accompanied by cyclization with formation of triazolothiadiazoles containing a 1,4-benzodioxane substituent. 4-Amino-5-(1,4-benzodioxan-2-yl)-4H-1,2,4-triazole-3-thiol reacted with substituted benzaldehydes to afford the corresponding Schiff bases, and its alkylation with chloroacetic acid in ethanol in the presence of sodium acetate gave S-ethoxycarbonylmethyl derivative.

Russian Journal of Organic Chemistry. 2017;53(3):428-432
pages 428-432 views

New 2-substituted functionalized allyl halides in the synthesis of fragments of amphidinolides B, D, G, H, and L

Mineeva I.V.

Abstract

Simple and efficient asymmetric syntheses of several new allyl bromides as C9–C14 fragments of cytotoxic macrolactones, amphidinolides B, D, G, H, and L, have been developed starting from accessible 1-[(2S)-4,4-dimethoxy-2-methylbutyl]cyclopropyl methanesulfonate prepared through cyclopropanol intermediates. Original synthetic approaches to the C7–C16, C7–C14, and C9–C16 amphidinolide fragments are also described.

Russian Journal of Organic Chemistry. 2017;53(3):433-444
pages 433-444 views

Synthesis of 3′H-cyclopropa[1,9](C60-Ih)[5,6]fullerenes from 2′-aryl-1′,1′-dimethyl-2′,5′-dihydro-1′H-pyrrolo[3′,4′:1,9]-(C60-Ih)[5,6]fulleren-1-ium iodides

Markin G.V., Ketkov S.Y., Lopatin M.A., Shavyrin A.S., Kuropatov V.A., Domrachev G.A.

Abstract

New 1′,1′-dimethyl-2′,5′-dihydro-1′H-pyrrolo[3′,4′:1,9](C60-Ih)[5,6]fulleren-1-ium iodides containing different aryl groups in position 2 of the pyrrolidine ring have been synthesized. Their reactions with bis-(toluene)chromine afforded the corresponding 3′-aryl-3′H-cyclopropa[1,9](C60-Ih)[5,6]fullerenes.

Russian Journal of Organic Chemistry. 2017;53(3):445-448
pages 445-448 views

1,1,1-Trifluoroethane encapsulated in fullerenes: Structural and conformational features

Kuznetsov V.V.

Abstract

DFT PBE/3ζ study of the structure and conformations of 1,1,1-trifluoroethane molecule encapsulated in fullerenes C60 and C80, as well as in their analogs with boron–nitrogen units, showed that the encapsulated molecule is characterized by shortened C–C bond, negative charge, and considerably increased barrier to rotation about the carbon–carbon bond. All mentioned effects diminish in the case of C60 doped with boron and nitrogen atoms.

Russian Journal of Organic Chemistry. 2017;53(3):449-453
pages 449-453 views

Three-component synthesis of 3-(diarylmethyl)indoles using Fe(ClO4)3/SiO2 as catalyst

Najafi E., Behbahani F.K.

Abstract

Three-component reaction of indole, aromatic aldehyde, and N,N-dimethyl aniline in the presence of silica-supported Fe(ClO4)3 as catalyst afforded the corresponding 3-[aryl(4-dimethylaminophenyl)methyl]-indoles in excellent yields under mild conditions. The proposed protocol offers some remarkable advantages such as the use of a solid catalyst and simple workup procedure.

Russian Journal of Organic Chemistry. 2017;53(3):454-458
pages 454-458 views

New synthesis of 4-methoxyisophthalic acid

Liu X.J., Yan Y.N., Wang S.Q., Li X., Liu X.G.

Abstract

A new synthetic route to 4-methoxyisophthalic acid, the key intermediate in the synthesis of Picotamide, is reported. The new protocol starts from commercially available and cheap 4-methylphenol and includes four steps: esterification, Fries rearrangement, methylation, and oxidation; the overall yield is 49%. Unlike the traditional Blanc chloromethylation/oxidation scheme, the proposed procedure avoids using volatile and corrosive hydrochloric acid.

Russian Journal of Organic Chemistry. 2017;53(3):459-461
pages 459-461 views

Short Communications

Synthesis of tetracyanoethylene by oxidative dimerization of malononitrile

Kachanov A.V., Slabko O.Y., Kaminskii V.A.

Abstract

A simple laboratory procedure has been proposed for the synthesis of tetracyanoethylene in up to 54% yield by oxidative dimerization of malononitrile in the presence of selenium(IV) oxide.

Russian Journal of Organic Chemistry. 2017;53(3):462-464
pages 462-464 views

Reaction of phosphorylated 2,6-di-tert-butyl-4-methylenecyclohexa-2,5-dien-1-ones with 2,2′-[1,3-phenylenebis(oxy)]-di(ethan-1-amine)

Gibadullina E.M., Thu N.T., Azmukhanova R.R., Burilov A.R., Pudovik M.A., Strelnik A.G.

Abstract

Dialkyl [(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]phosphonates reacted with 2,2′-[1,3-phenylenebis(oxy)]di(ethan-1-amine) dihydrochloride at a ratio of 2: 1 in dioxane in the presence of potassium carbonate to give previously unknown tetraalkyl {1,3-phenylenebis[oxyethane-2,1-diylazanediyl-(3,5-di-tert-butyl-4-hydroxyphenylmethylene)]}bisphosphonates in high yields.

Russian Journal of Organic Chemistry. 2017;53(3):465-467
pages 465-467 views

Convenient synthesis of 1-hydrazinylanthracene-9,10-diones

Stasevych M.V., Zvarych V.I., Lunin V.V., Vovk M.V., Novikov V.P.

Abstract

An efficient procedure has been proposed for the synthesis of previously unknown 1-hydrazinylanthraquinones containing acyl and/or ester fragments convenient for subsequent transformations.

Russian Journal of Organic Chemistry. 2017;53(3):468-469
pages 468-469 views

Formation of 2-methyl-3,5-diphenylfuran from chalcone and acetylene in the system KOH–DMSO

Bidusenko I.A., Cherimichkina N.A., Schmidt E.Y., Trofimov B.A.

Abstract

Chalcone reacted with acetylene in a suspension of KOH in DMSO at 90°C (30 min) to give 36% of 2-methyl-3,5-diphenylfuran.

Russian Journal of Organic Chemistry. 2017;53(3):470-471
pages 470-471 views

Epimeric sulfoxides derived from 8-methyl-5-(methylsulfanylmethyl)-3-thiabicyclo[3.3.1]non-7-en-6-one

Baeva L.A., Fatykhov A.A., Lyapina N.K.

Abstract

Epimeric mono- and bis-sulfoxides synthesized by oxidation of 8-methyl-5-(methylsulfanylmethyl)-3-thiabicyclo[3.3.1]non-7-en-6-one were separated by silica gel column chromatography. Their threo and erythro isomers were distinguished by signals of diastereotopic protons of the exocyclic methylene group.

Russian Journal of Organic Chemistry. 2017;53(3):472-473
pages 472-473 views

Convenient synthesis of 3-chloroimidazo[1,5-a]quinoxalines

Chornous V.A., Grozav A.N., Vovk M.V.

Abstract

5-Aminomethyl-1-(2-haloaryl)-4-chloroimidazoles prepared from 1-(2-haloaryl)-5-formyl-4-chloroimidazoles via simple transformations undergo intramolecular cyclization to 3-chloroimidazo[1,5-a]quinoxalines on heating in DMF in the presence of potassium carbonate.

Russian Journal of Organic Chemistry. 2017;53(3):474-476
pages 474-476 views

Structure of the trifluoroacetylation product of 1-ethyl-6-methoxy-3-methyl-1H-1,2-diazaphenalene

Omelichkin N.I., Kuz’mina L.G., Minyaeva L.G., Mezheritskii V.V.

Abstract

1-Ethyl-6-methoxy-3-methyl-1H-1,2-diazaphenalene was readily acylated with trifluoroacetic anhydride with formation of 1-ethyl-6-methoxy-3-methyl-7,9-bis(trifluoroacetyl)-1H-1,2-diazaphenalene.

Russian Journal of Organic Chemistry. 2017;53(3):477-478
pages 477-478 views

Synthesis of [4-amino-5-(R-benzyl)-1,3-thiazol-2-ylsulfanyl] acetic acids

Ostapyuk Y.V., Matiichuk V.S., Obushak M.D.

Abstract

(4-Amino-1,3-thiazol-2-ylsulfanyl)acetic acids were synthesized by reaction of α-thiocyanatonitriles with sulfanylacetic acid in boiling acetonitrile.

Russian Journal of Organic Chemistry. 2017;53(3):479-480
pages 479-480 views

Convenient synthesis of 1-norbornyl-5-R-1H-1,2,3-triazole-4-carboxylic acids

Pokhodylo N.T., Matiichuk V.S., Obushak M.D.

Abstract

A convenient procedure was developed for the synthesis of 2-azidobicyclo[2.2.1]heptane whose click reaction with phenylacetylene afforded 1-(bicyclo[2.2.1]heptan-2-yl)-4-phenyl-1H-1,2,3-triazol, and its reactions with ethyl α-bromoacrylate and ethyl acetoacetate gave 1-(bicyclo[2.2.1]heptan-2-yl)-5-R-1H-1,2,3-triazole-4-carboxylic acids.

Russian Journal of Organic Chemistry. 2017;53(3):481-483
pages 481-483 views