Chemistry of Iminofuran: XVI. Synthesis, Structure, Biological Activity, and Cyclization of 4-Oxo-2-(2-phenylaminobenzoylhydrazono)butanoic Acids
- 作者: Kizimovaa I.A.1, Igidov N.M.1, Chaschina S.V.1, Chernov I.N.2, Rubtsov A.E.3
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隶属关系:
- Perm State Pharmaceutical Academy
- Scientific Research Institute of Chemistry
- Perm State National Research University
- 期: 卷 55, 编号 11 (2019)
- 页面: 1704-1711
- 栏目: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/221363
- DOI: https://doi.org/10.1134/S1070428019110101
- ID: 221363
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详细
The reaction of (2-phenylaminobenzoyl)hydrazine with 4-aryl-2-hydroxy-4-oxobut-2-enoic and 2-hydroxy-5,5-dimethyl-4-oxohex-2-enoic acids results in the formation of 4-aryl-2-(2-phenylaminobenzoyl-hydrazono)-4-oxobutanoic and 5,5-dimethyl-2-(2-phenylaminobenzoylhydrazono)-4-oxohexanoic acids. The products in solutions are present as mixtures of a Z,E-hydrazono form and a cyclic pyrazolinic form, and under the action of acetic anhydride they cyclize in 5-aryl- and 5-tert-butyl-3-(2-phenylaminobenzoylhydrazono)-furan-2,3-diones. 4-Aryl-2-(2-phenylaminobenzoylhydrazono)-4-oxobutanoic and 5,5-dimethyl-2-(2-phenyl-aminobenzoylhydrazono)-4-oxohexanoic acids were tested for antinociceptive and anti-inflammatory activity.
作者简介
I. Kizimovaa
Perm State Pharmaceutical Academy
Email: rubtsov@psu.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990
N. Igidov
Perm State Pharmaceutical Academy
Email: rubtsov@psu.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990
S. Chaschina
Perm State Pharmaceutical Academy
Email: rubtsov@psu.ru
俄罗斯联邦, ul. Polevaya 2, Perm, 614990
I. Chernov
Scientific Research Institute of Chemistry
Email: rubtsov@psu.ru
俄罗斯联邦, pr. Gagarina 23, Nizhny Novgorod, 603022
A. Rubtsov
Perm State National Research University
编辑信件的主要联系方式.
Email: rubtsov@psu.ru
俄罗斯联邦, ul. Bukireva 15, Perm, 614990
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