Email this article New Key Building Block for Ixabepilone from R-(-)-Carvone
- Authors: Valeev R.F.1, Sunagatullina G.R.1, Miftakhov M.S.1
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Affiliations:
- Ufa Institute of Chemistry, Ufa Federal Research Center
- Issue: Vol 55, No 9 (2019)
- Pages: 1370-1373
- Section: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/221174
- DOI: https://doi.org/10.1134/S1070428019090161
- ID: 221174
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Abstract
A synthetic approach is described for the transformation of R-(-)-carvone to methyl (2Z,5S,6E)-5-[(tert-butoxycarbonyl)amino]-2,6-dimethyl-7-(2-methyl-1,3-thiazol-4-yl)hepta-2,6-dienoate, the key building block for the convergent synthesis of the known antitumor macrolactam ixabepilone. The synthetic sequence includes 10 stages, where the key stage is Curtius rearrangement. Optimal conditions have been found for that rearrangement.
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About the authors
R. F. Valeev
Ufa Institute of Chemistry, Ufa Federal Research Center
Author for correspondence.
Email: rusl0@yandex.ru
Russian Federation, Ufa, Bashkortostan
G. R. Sunagatullina
Ufa Institute of Chemistry, Ufa Federal Research Center
Email: rusl0@yandex.ru
Russian Federation, Ufa, Bashkortostan
M. S. Miftakhov
Ufa Institute of Chemistry, Ufa Federal Research Center
Email: rusl0@yandex.ru
Russian Federation, Ufa, Bashkortostan
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