Email this article Substituted 2-(2-Arylethenyl)quinazolines. Synthesis and Structure
- Authors: Harutyunyan A.A.1,2, Gukasyan G.T.1, Panosyan H.A.2, Tamazyan R.A.2, Ayvazyan A.G.2, Danagulyan G.G.1,2
-
Affiliations:
- Russian Armenian (Slavic) University
- Scientific Technological Center of Organic and Pharmaceutical Chemistry
- Issue: Vol 55, No 9 (2019)
- Pages: 1363-1369
- Section: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/221169
- DOI: https://doi.org/10.1134/S107042801909015X
- ID: 221169
Cite item
Open Access
Access granted
Subscription Access
Abstract
The reaction of 2-methyl-4H-3,1-benzoxazin-4-one and its 6-iodo derivatives with a number of amines in polyphosphoric acid afforded 3- and 3,6-substituted 2-methylquinazolin-4(3H)-ones. The latter reacted with aromatic and heterocyclic aldehydes under solvent-free conditions to give 2-[(E)-2-arylethenyl]-quinazolin-4(3H)-ones. The structure of the synthesized compounds was confirmed by two-dimensional 1H–1H NOESY data and X-ray analysis.
About the authors
A. A. Harutyunyan
Russian Armenian (Slavic) University; Scientific Technological Center of Organic and Pharmaceutical Chemistry
Author for correspondence.
Email: harutyunyan.arthur@yahoo.com
Armenia, Yerevan; Yerevan
G. T. Gukasyan
Russian Armenian (Slavic) University
Email: harutyunyan.arthur@yahoo.com
Armenia, Yerevan
H. A. Panosyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry
Email: harutyunyan.arthur@yahoo.com
Armenia, Yerevan
R. A. Tamazyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry
Email: harutyunyan.arthur@yahoo.com
Armenia, Yerevan
A. G. Ayvazyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry
Email: harutyunyan.arthur@yahoo.com
Armenia, Yerevan
G. G. Danagulyan
Russian Armenian (Slavic) University; Scientific Technological Center of Organic and Pharmaceutical Chemistry
Email: harutyunyan.arthur@yahoo.com
Armenia, Yerevan; Yerevan
Supplementary files
