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Synthesis and Anticancer Activity of Certain Selenophene Derivatives


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Abstract

Selenopheno[2,3-d]pyrimidine- and selenopheno[2,3-d][1,2,3]triazine-containing compounds were synthesized starting from 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]selenophene-3-carbonitrile. In vitro anticancer activity of the newly synthesized compounds was tested using 60 different human cancer cell lines.

About the authors

M. E. Adly

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy

Author for correspondence.
Email: mina.magharyos@pharma.cu.edu.eg
Egypt, Cairo, 11562

E. M. Gedawy

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy; Pharmaceutical Chemistry Department, Faculty of Pharmacy and Pharmaceutical Industries

Email: mina.magharyos@pharma.cu.edu.eg
Egypt, Cairo, 11562; Cairo, 11829

A. A. El-Malah

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy; Pharmaceutical Chemistry Department, Faculty of Pharmacy and Drug Technology

Email: mina.magharyos@pharma.cu.edu.eg
Egypt, Cairo, 11562; Cairo, 11785

F. A. El-Telbany

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy

Email: mina.magharyos@pharma.cu.edu.eg
Egypt, Cairo, 11562

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