Efficient Three-Component One-Pot Synthesis of 4H-Pyrans

Abstract

Clean, practical, and efficient electrochemical synthesis of pharmaceutically relevant 4H-pyran derivatives by one-pot three-component combination of an aryl aldehyde, malononitrile, and a dicarbonyl compoundis developed. The synthesis is performed in ethanol with lithium perchlorate as a supporting electrolyte in an undivided cell on a platinum electrode under constant potential electrolysis conditions.