Efficient One-Pot Synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11-trione Derivatives Catalyzed by Y(OTf)3
- 作者: Turhan K.1, Turgut Z.1
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隶属关系:
- University of Yildiz Technical, Faculty of Art and Sciences, Department of Chemistry
- 期: 卷 55, 编号 2 (2019)
- 页面: 250-253
- 栏目: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/219929
- DOI: https://doi.org/10.1134/S1070428019020180
- ID: 219929
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详细
In this study, substituted 2H-indazolo[2,1-b]phthalazine-1,6,11-triones, that may possess biological activity, have been synthesized via one-pot three-component cyclocondensation reaction of aromatic aldehydes, cyclic 1,3-dione and phthalhydrazide in ethanol catalyzed by Y(OTf)3 with good to excellent yields. The structures of all synthesized compounds, 3,4-dihydro-13-phenyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4a), 13-(4-cyanophenyl)-3,4-dihydro-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4b), 3,4-dihydro-3,3-dimethyl-13-(4-cyanophenyl)-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4c), 3,4-dihydro-3,3-dimethyl-13-phenyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4d), and 3,4-dihydro-13-(4-isopropylphenyl)-3,3-dimethyl-2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione (4e) have been elucidated from IR, NMR and mass spectral data.
作者简介
K. Turhan
University of Yildiz Technical, Faculty of Art and Sciences, Department of Chemistry
编辑信件的主要联系方式.
Email: kturhan@yildiz.edu.tr
土耳其, Istanbul, 34210
Z. Turgut
University of Yildiz Technical, Faculty of Art and Sciences, Department of Chemistry
编辑信件的主要联系方式.
Email: zturgut@yildiz.edu.tr
土耳其, Istanbul, 34210
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